1. Anti-infection
    Cell Cycle/DNA Damage
  2. SARS-CoV
    Enterovirus
    HCV
    Topoisomerase
  3. EIDD-1931

EIDD-1931 (Synonyms: β-D-N4-hydroxycytidine; NHC)

Cat. No.: HY-125033 Purity: 99.73%
Handling Instructions

EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is a novel nucleoside analog and behaves as a potent anti-virus agent. EIDD-1931 effectively inhibits the replication activity of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV).

For research use only. We do not sell to patients.

EIDD-1931 Chemical Structure

EIDD-1931 Chemical Structure

CAS No. : 3258-02-4

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Based on 2 publication(s) in Google Scholar

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Description

EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is a novel nucleoside analog and behaves as a potent anti-virus agent. EIDD-1931 effectively inhibits the replication activity of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV)[1].

In Vitro

Beta-d-N4-hydroxycytidine is an anti-VEEV (venezuelan equine encephalitis virus) agent with EC50, EC90, and EC99 are 0.426, 1.036, and 2.5 μM, respectively[1].
Beta-d-N4-hydroxycytidine inhibits CHIKV replicon activity and the 50% effective concentration (EC50) s 0.8 μM in the Huh-7–CHIKV replicon cell line. Similar results is presented with the replicon in BHK-21 cells (EC50=1.8 μM)[2].
NHC has no cytotoxicity for NHC in the Huh-7 cell culture system until up to 100 μM using MTT assays. The 50% cytotoxic concentration (CCsub>50) values for NHC are determined to be 30.6 μM, 7.7 μM, and 2.5 μM in peripheral blood mononuclear (PBM), Vero, and CEM cells, respectively[2].
NHC behaves as a pyrimidine analog, NHC-mediated inhibition of the CHIKV replicon can be abrogated by the addition of exogenous nucleosides, such as pyrimidines C and U, but dA, dC, dG, dU, or T has no impact on the replicon. Pyrimidines A and G contributes to replicon inhibition both in the presence and in the absence of NHC[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

259.22

Formula

C₉H₁₃N₃O₆

CAS No.

3258-02-4

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (385.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8577 mL 19.2886 mL 38.5773 mL
5 mM 0.7715 mL 3.8577 mL 7.7155 mL
10 mM 0.3858 mL 1.9289 mL 3.8577 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.02 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.02 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.02 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.73%

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Keywords:

EIDD-1931β-D-N4-hydroxycytidine NHCEIDD1931EIDD 1931SARS-CoVEnterovirusHCVTopoisomeraseSARS coronavirusRhinovirusHRVHRVsHEVHEVsHepatitis C virusEnterovirus,VEEVCHIKVvenezuelanequineencephalitisChikungunyaInhibitorinhibitorinhibit

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Product Name:
EIDD-1931
Cat. No.:
HY-125033
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