1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. Doxorubicinol hydrochloride

Doxorubicinol hydrochloride (Synonyms: 13-Dihydroadriamycin hydrochloride)

Cat. No.: HY-G0022
Handling Instructions

Doxorubicinol hydrochloride (13-Dihydroadriamycin hydrochloride) is a secondary alcohol metabolite of Doxorubicin.

For research use only. We do not sell to patients.

Doxorubicinol hydrochloride Chemical Structure

Doxorubicinol hydrochloride Chemical Structure

CAS No. : 63950-05-0

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Description

Doxorubicinol hydrochloride (13-Dihydroadriamycin hydrochloride) is a secondary alcohol metabolite of Doxorubicin[1].

In Vitro

Doxorubicinol hydrochloride is produced by a two-electron, NADPH-dependent reduction of the Doxorubicin side-chain carbonyl group (C13) to a secondary alcohol[1].
Doxorubicinol hydrochloride has been shown to have significantly lower DNA binding activity as compared to DOX. Moreover, while Doxorubicinol hydrochloride is retained in the cytoplasm or lysosomes, Doxorubicin is mainly accumulated in the nucleus[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In vivo, in tumor-bearing mice, Nilotinib, acting as ABCB1 inhibitor, is found to increase the accumulation of Doxorubicin and Doxorubicinol hydrochloride in cancer tissues. This implies that weaker anticancer activity of Doxorubicinol hydrochloride may be related to its increased affinity to ABC transporters, thus leading to a lower intracellular concentration of the agent[1].
In comparison with wild-type mice, the terminal half-life and the area under the plasma concentration-time curve of Doxorubicin in mdr1a(-/-) mice are 1.6- and 1.2-fold higher respectively. The retention of both Doxorubicin and its metabolite Doxorubicinol hydrochloride in the hearts of mdr1a(-/-) mice is substantially prolonged[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

582.00

Formula

C₂₇H₃₂ClNO₁₁

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Doxorubicinol hydrochloride
Cat. No.:
HY-G0022
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