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Cat. No.: HY-121259

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Doxorubicinol

(Synonyms: Adriamycinol; DXR-OL)

Doxorubicinol, a potent inhibitor of the cardiac sarcoplasmic reticulum calcium pump, inhibits systolic myocardial function in isolated heart muscle. Doxorubicinol inhibits tumor cell growth and has cardiotoxicity.

For research use only. We do not sell to patients.

CAS No.: 54193-28-1
Formula: C₂₇H₃₁NO₁₁
Molecular Weight:545.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Doxorubicinol Chemical Structure

CAS No.: 54193-28-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

Doxorubicinol inhibits diastolic function (i.e., increased resting pressure) of isolated papillary muscles^[1].
Doxorubicinol almost completely abrogates calcium pump activity at concentrations that significantly reduce diastolic function^[1].
Doxorubicinol inhibits Ca2+-stimulated ATPase activity of the sarcoplasmic reticulum of skeletal muscle and abolishes Na+/K+-ATPase activity of the sarcolemma in canine and rabbit heart preparations^[1].
Doxorubicinol inhibits the proliferation of PANC-1 cells with IC₅₀ value of 35.4 μM, PD PaCa cells with IC₅₀ value of 44.5 μM, WD PaCa cells with IC₅₀ value of 49.5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 54193-28-1
Molecular Weight 545.54
Formula C₂₇H₃₁NO₁₁
SMILES

O=C1C2=C(C3=C(C(O)=C2C(C4=C1C=CC=C4OC)=O)[C@@H](O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)N)C[C@](O)([C@H](CO)O)C3)O
Synonyms

Adriamycinol; DXR-OL
Structure Classification
- Quinones
- Anthraquinones
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Olson RD, et al. Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol. Proc Natl Acad Sci U S A. 1988 May;85(10):3585-9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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