1. Anti-infection
    Cell Cycle/DNA Damage
    Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Apoptosis
  2. HIV
    DNA/RNA Synthesis
    HBV
    Reactive Oxygen Species
    Apoptosis
  3. AZT triphosphate TEA

AZT triphosphate TEA (Synonyms: 3'-Azido-3'-deoxythymidine-5'-triphosphate TEA)

Cat. No.: HY-116364A
Handling Instructions

AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway.

For research use only. We do not sell to patients.

AZT triphosphate TEA Chemical Structure

AZT triphosphate TEA Chemical Structure

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Description

AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3].

IC50 & Target

HIV[2]
HBV[3]
DNA polymerase[3]
Reactive oxygen species (ROS)[1]

In Vitro

Treatment with 100 µM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Formula

C₁₀H₁₆N₅O₁₃P₃.xC₆H₁₅N

SMILES

O=C(NC(C(C)=C1)=O)N1[[email protected]](O2)C[[email protected]](N=[N+]=[N-])[[email protected]]2COP(O)(OP(OP(O)(O)=O)(O)=O)=O.CCN(CC)CC.[x]

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AZT triphosphate3'-Azido-3'-deoxythymidine-5'-triphosphateHIVDNA/RNA SynthesisHBVReactive Oxygen SpeciesApoptosisHuman immunodeficiency virusHepatitis B virusZidovudinetriphosphatemetaboliteROSmitochondrialcardiomyopathyOpa1Drp1cytotoxicityantiretroviralInhibitorinhibitorinhibit

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AZT triphosphate TEA
Cat. No.:
HY-116364A
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