1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Glucocorticoid Receptor
    Drug Metabolite
  3. Beclomethasone 17-propionate

Beclomethasone 17-propionate (Synonyms: Beclomethasone-17-monopropionate; 17-BMP)

Cat. No.: HY-136239
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Beclomethasone 17-propionate (Beclomethasone-17-monopropionate), an active metabolite of Beclomethasone dipropionate (HY-13571), is a glucocorticoid receptor (GR) agonist. Beclomethasone 17-propionate exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in chronic obstructive pulmonary disease (COPD) lung macrophages.

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Beclomethasone 17-propionate Chemical Structure

Beclomethasone 17-propionate Chemical Structure

CAS No. : 5534-18-9

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Description

Beclomethasone 17-propionate (Beclomethasone-17-monopropionate), an active metabolite of Beclomethasone dipropionate (HY-13571), is a glucocorticoid receptor (GR) agonist. Beclomethasone 17-propionate exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in chronic obstructive pulmonary disease (COPD) lung macrophages[1][2][3].

In Vitro

Metabolism of Beclomethasone dipropionate to 17-BMP is an important activation step. Beclomethasone 17-propionate inhibits LPS-stimulated CXCL8, TNFα and IL-6. The EC50 values of Beclomethasone 17-propionate for IL-6, TNFα and CXCL8 were 0.05 nM, 0.01 nM and 0.1 nM, respectively. Beclomethasone 17-propionate evokes upregulation of the GR dependent genes FKBP51 and GILZ[3].

Molecular Weight

464.98

Formula

C₂₅H₃₃ClO₆

CAS No.

5534-18-9

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Keywords:

Beclomethasone 17-propionateBeclomethasone-17-monopropionate17-BMPGlucocorticoid ReceptorDrug MetaboliteCOPDmetabolitecytokineCXCL8TNFαIL-6FKBP51GILZInhibitorinhibitorinhibit

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Beclomethasone 17-propionate
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