1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Glucocorticoid Receptor
    Drug Metabolite
  3. Beclomethasone 17-propionate

Beclomethasone 17-propionate (Synonyms: Beclomethasone-17-monopropionate; 17-BMP)

Cat. No.: HY-136239
Handling Instructions

Beclomethasone 17-propionate (Beclomethasone-17-monopropionate), an active metabolite of Beclomethasone dipropionate (HY-13571), is a glucocorticoid receptor (GR) agonist. Beclomethasone 17-propionate exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in chronic obstructive pulmonary disease (COPD) lung macrophages.

For research use only. We do not sell to patients.

Beclomethasone 17-propionate Chemical Structure

Beclomethasone 17-propionate Chemical Structure

CAS No. : 5534-18-9

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Solution
10 mM * 1 mL in DMSO USD 256 Ask For Quote & Lead Time
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Description

Beclomethasone 17-propionate (Beclomethasone-17-monopropionate), an active metabolite of Beclomethasone dipropionate (HY-13571), is a glucocorticoid receptor (GR) agonist. Beclomethasone 17-propionate exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in chronic obstructive pulmonary disease (COPD) lung macrophages[1][2][3].

In Vitro

Metabolism of Beclomethasone dipropionate to 17-BMP is an important activation step. Beclomethasone 17-propionate inhibits LPS-stimulated CXCL8, TNFα and IL-6. The EC50 values of Beclomethasone 17-propionate for IL-6, TNFα and CXCL8 were 0.05 nM, 0.01 nM and 0.1 nM, respectively. Beclomethasone 17-propionate evokes upregulation of the GR dependent genes FKBP51 and GILZ[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

464.98

Formula

C₂₅H₃₃ClO₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (215.06 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1506 mL 10.7532 mL 21.5063 mL
5 mM 0.4301 mL 2.1506 mL 4.3013 mL
10 mM 0.2151 mL 1.0753 mL 2.1506 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Beclomethasone 17-propionate
Cat. No.:
HY-136239
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