1. Cytoskeleton
  2. Gap Junction Protein
  3. Carbenoxolone disodium

Carbenoxolone disodium 

Cat. No.: HY-B1367 Purity: 99.29%
Handling Instructions

Carbenoxolone disodium is the active metabolite of Glycyrrhizic acid (HY-N0184) and the inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD. Carbenoxolone disodium is an uncoupling agent for gap junctions and a potent inhibitor of Vaccinia virus replication. Carbenoxolone disodium is used for the study of peptic, esophageal and oral ulceration and inflammation.

For research use only. We do not sell to patients.

Carbenoxolone disodium Chemical Structure

Carbenoxolone disodium Chemical Structure

CAS No. : 7421-40-1

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10 mM * 1  mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
25 mg USD 80 In-stock
Estimated Time of Arrival: December 31
50 mg USD 135 In-stock
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100 mg USD 230 In-stock
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Description

Carbenoxolone disodium is the active metabolite of Glycyrrhizic acid (HY-N0184) and the inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD[1]. Carbenoxolone disodium is an uncoupling agent for gap junctions and a potent inhibitor of Vaccinia virus replication[2]. Carbenoxolone disodium is used for the study of peptic, esophageal and oral ulceration and inflammation.

IC50 & Target

IC50: human 11β-HSD; bacterial 3α, 20β-HSD[1]; gap junction; Vaccinia virus[2]

In Vitro

Carbenoxolone disodium (6-150 μM; pre-treatment 1 hour) inhibits Vaccinia virus (VACV) replication in a gap junction-independent in HaCaT cells, and it has toxicity effects on VACV-A5L-EGFP infected cells at 48 h[2].
Carbenoxolone (30 μM; pre-treatment 1 hour) does not upregulate PP2A expression, but induces the late protein A27 expression in hacat cells[2].

Cell Viability Assay[2]

Cell Line: HaCaT cells
Concentration: 6 μM, 12 μM, 30 μM, 60 μM, 150 μM
Incubation Time: Pre-treatment 1 hour
Result: Had no toxicity until 48 hours at high dose in virus-infected cells.

Western Blot Analysis[2]

Cell Line: HaCaT cells
Concentration: 30 μM
Incubation Time: Pre-treatment 1 hour
Result: Presented an obvious upregulation of A27.
In Vivo

Carbenoxolone (intraperitoneal injection; 100, 200 and 300 mg/kg; 30, 60 and 60 min before Diazepam) does not induce a muscle relaxant activity and shows muscle relaxant activity compared to normal saline, and this effect was more than diazepam in the traction test[3].
Carbenoxolone (intraperitoneal injection; 100, 200 and 300 mg/kg; 30, 60 and 60 min before Pentylenetetrazole) significantly increases sleeping time and decreases latency in mice as a dose-dependent manner in Pentylenetetrazole (PTZ) Seizure model. The ED50 value is 83.3 mg/kg (%95 CL:556.29)[3].

Animal Model: Male BALB/c mice[3]
Dosage: 100, 200 and 300 mg/kg
Administration: Intraperitoneal injection; 30, 60 and 60 min before Pentylenetetrazole
Result: Significantly increased the sleeping time in mice.
Molecular Weight

614.72

Formula

C₃₄H₄₈Na₂O₇

CAS No.

7421-40-1

SMILES

CC(C)([[email protected]]1([H])CC[[email protected]@]([[email protected]@]2(CC[[email protected]]3(CC[[email protected]](C[[email protected]@]3([H])C2=C4)(C)C(O[Na])=O)C)C)5C)[[email protected]@H](OC(CCC(O[Na])=O)=O)CC[[email protected]]1(C)[[email protected]@]5([H])C4=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

Carbenoxolone disodiumGap Junction Proteinglycyrrhetinicacidderivativepepticesophagealoral ulcerationinflammation,?creamVaccinia virusVACV?anticonvulsantmuscle relaxanthypnoticInhibitorinhibitorinhibit

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