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Ilimaquinone 

Cat. No.: HY-119500
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Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus. Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects.

For research use only. We do not sell to patients.

Ilimaquinone Chemical Structure

Ilimaquinone Chemical Structure

CAS No. : 71678-03-0

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Description

Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus[1]. Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects[2].

In Vitro

Ilimaquinone induces a concentration-dependent anti-proliferative effect in several types of cancer cell lines, including prostate cancer PC-3 and LNCaP, non-small cell lung cancer A549 and hepatocellular carcinoma Hep3B cells. Ilimaquinone (0.3-30 μM ; 48 hours) inhibits the proliferation of PC-3 cells, DU145, LNCaP, MG63, A549, Hep3B cells with GI50s of 2.6 μM, 5.8, 4.6, 4.9, 4.1, 12.0μM, respectively[1].

Cell Viability Assay[1]

Cell Line: Prostate cancer PC-3 cells
Concentration: 0.3, 1, 3, 10, and 30 μM
Incubation Time: 48 hours
Result: Inhibited the proliferation of PC-3 cells in a concentration-dependent manner.
In Vivo

Ilimaquinone exhibits terminal elimination half-lives (T1/2=1.2±0.3 h) due to high plasma clearance (2.95±0.53 L/h/kg) following oral administration (10 mg/kg) in male Sprague-Dawley rats[2].

Molecular Weight

358.47

Formula

C₂₂H₃₀O₄

CAS No.

71678-03-0

SMILES

C=C1[[email protected]]2(CC[[email protected]@H]([[email protected]](C)([[email protected]@]2(CCC1)[H])CC3=C(C(C=C(C3=O)OC)=O)O)C)C

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

IlimaquinoneHIVBacterialHuman immunodeficiency virusmarinespongemetaboliteanticancerGADD153Golgiapparatusanti-HIVanti-microbialanti-inflammatoryInhibitorinhibitorinhibit

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Ilimaquinone
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HY-119500
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