Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta

  • J Nat Prod. 2004 Oct;67(10):1716-8. doi: 10.1021/np049849+.
Shugeng Cao  1 ,  Zhijie Gao ,  Shannon J Thomas ,  Sidney M Hecht ,  John S Lazo ,  David G I Kingston
Affiliations
  • 1. Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA.
PMID: 15497946 DOI: 10.1021/np049849+
Abstract

Bioassay-directed fractionation of an extract of the marine species Spongia sp. led to the discovery of the new sesquiterpenoid derivative 17-O-isoprenyldictyoceratin-C (1), the known sesquiterpenoid derivative dictyoceratin-C (2), and the sesquiterpenoid quinone ilimaquinone (3), in addition to the nucleoside 2'-deoxyuridine. The structure of the new compound 1 was determined on the basis of spectroscopic methods and by conversion of dictyoceratin-C (2) to 1.