New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities

  • Bioorg Med Chem Lett. 2017 Jul 15;27(14):3043-3047. doi: 10.1016/j.bmcl.2017.05.060.
Hien Minh Nguyen  1 ,  Takuya Ito  2 ,  Shin-Ichiro Kurimoto  3 ,  Mika Ogawa  3 ,  Nwet Nwet Win  4 ,  Vo Quoc Hung  5 ,  Hoai Thi Nguyen  5 ,  Takaaki Kubota  3 ,  Jun'ichi Kobayashi  6 ,  Hiroyuki Morita  7
Affiliations
  • 1. Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
  • 2. Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: [email protected].
  • 3. Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.
  • 4. Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan; Department of Chemistry, University of Yangon, Yangon 11041, Myanmar.
  • 5. Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue City, Viet Nam.
  • 6. Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
  • 7. Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: [email protected].
PMID: 28558970 DOI: 10.1016/j.bmcl.2017.05.060
Abstract

The investigation of the Vietnamese marine Sponge Spongia sp. led to the isolation of three new sesquiterpene Phenols, langconols A-C (1-3), and one new sesquiterpene hydroxyquinone, langcoquinone C (4), together with two known meroterpenoids (5 and 6). Their structures were determined on the basis of spectroscopic analyses and comparisons with published data. Furthermore, the Antibacterial assays of the isolates 1-6 suggested that 4 and 6 had significant Antibacterial activities against Bacillus subtilis and Staphylococcus aureus, with MICs ranging from 6.25 to 25.0µM, while 1 and 3 possessed significant Antibacterial activities against B. subtilis with MICs of 12.5 and 25.0µM, respectively. In contrast, cytotoxic assays of the isolated compounds 1-6, as well as compounds 7-15 previously isolated from this Sponge, indicated that 1 and the previously reported anti-B. subtilis and anti-S. aureus sesquiterpene phenol 9 lacked cytotoxic activities against three human Cancer cell lines (A549, lung cancer; MCF7, breast cancer; HeLa, cervix Cancer) and a human normal cell line (WI-38 fibroblast).

Keywords
Antibacterial activity; Cytotoxic activity; Meroterpenoids; Spongia sp.; Vietnam.