1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor Dopamine Receptor
  3. Brexpiprazole S-oxide

Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM.

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Brexpiprazole S-oxide Chemical Structure

Brexpiprazole S-oxide Chemical Structure

CAS No. : 1191900-51-2

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Description

Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

IC50 & Target[2]

5-HT1A Receptor

0.12 nM (Ki)

5-HT2A Receptor

0.47 nM (Ki)

D2 Receptor

0.3 nM (Ki)

Molecular Weight

449.57

Formula

C25H27N3O3S

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1NC2=C(C=CC(OCCCCN3CCN(C4=C(C=CS5=O)C5=CC=C4)CC3)=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (55.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2243 mL 11.1217 mL 22.2435 mL
5 mM 0.4449 mL 2.2243 mL 4.4487 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2243 mL 11.1217 mL 22.2435 mL 55.6087 mL
5 mM 0.4449 mL 2.2243 mL 4.4487 mL 11.1217 mL
10 mM 0.2224 mL 1.1122 mL 2.2243 mL 5.5609 mL
15 mM 0.1483 mL 0.7414 mL 1.4829 mL 3.7072 mL
20 mM 0.1112 mL 0.5561 mL 1.1122 mL 2.7804 mL
25 mM 0.0890 mL 0.4449 mL 0.8897 mL 2.2243 mL
30 mM 0.0741 mL 0.3707 mL 0.7414 mL 1.8536 mL
40 mM 0.0556 mL 0.2780 mL 0.5561 mL 1.3902 mL
50 mM 0.0445 mL 0.2224 mL 0.4449 mL 1.1122 mL
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Brexpiprazole S-oxide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Brexpiprazole S-oxide
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