Brexpiprazole S-oxide
Based on 1 Customer Validation
Brexpiprazole S-oxide (DM-3411) is a metabolite of Brexpiprazole (HY-15780). Brexpiprazole S-oxide is a dopamine D2 receptor ligand that binds to the human dopamine D2L receptor with a Ki of 5.01 nM. Brexpiprazole S-oxide can be used for research on schizophrenia.
For research use only. We do not sell to patients.
- Purity : 96.51%
- CAS No.: 1191900-51-2
- Formula: C25H27N3O3S
- Molecular Weight:449.57
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Dopamine Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[2]|
D2 Receptor 5.01 nM (Ki) |
In Vitro
Brexpiprazole S-oxide (DM-3411) binds to the human D2L receptor with a Ki of 5.01 nM[2].
Brexpiprazole S-oxide exhibits high protein binding of 92.6% or more[2].
Brexpiprazole S-oxide (50 μM; 60 min) is the major S-oxide metabolite formed in RLM, HLM, and RS9 in vitro systems[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 1191900-51-2
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Appearance Solid
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Molecular Weight 449.57
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Formula C25H27N3O3S
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Color Off-white to light yellow
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SMILES
O=C1NC2=C(C=CC(OCCCCN3CCN(C4=C(C=CS5=O)C5=CC=C4)CC3)=C2)C=C1
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Synonyms
DM-3411
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (55.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2243 mL | 11.1217 mL | 22.2435 mL | 55.6087 mL |
| 5 mM | 0.4449 mL | 2.2243 mL | 4.4487 mL | 11.1217 mL | |
| 10 mM | 0.2224 mL | 1.1122 mL | 2.2243 mL | 5.5609 mL | |
| 15 mM | 0.1483 mL | 0.7414 mL | 1.4829 mL | 3.7072 mL | |
| 20 mM | 0.1112 mL | 0.5561 mL | 1.1122 mL | 2.7804 mL | |
| 25 mM | 0.0890 mL | 0.4449 mL | 0.8897 mL | 2.2243 mL | |
| 30 mM | 0.0741 mL | 0.3707 mL | 0.7414 mL | 1.8536 mL | |
| 40 mM | 0.0556 mL | 0.2780 mL | 0.5561 mL | 1.3902 mL | |
| 50 mM | 0.0445 mL | 0.2224 mL | 0.4449 mL | 1.1122 mL |
Brexpiprazole S-oxide Related Classifications
HY-133152 Related Classifications
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