1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor
  3. Brexpiprazole S-oxide

Brexpiprazole S-oxide (Synonyms: DM-3411)

Cat. No.: HY-133152
Handling Instructions

Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM.

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Brexpiprazole S-oxide Chemical Structure

Brexpiprazole S-oxide Chemical Structure

CAS No. : 1191900-51-2

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Description

Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

IC50 & Target

Ki: 0.12 nM (5-HT1A), 0.3 nM (D2L), 0.47 nM (5-HT2A)[2]

Molecular Weight

449.57

Formula

C₂₅H₂₇N₃O₃S

CAS No.

1191900-51-2

SMILES

O=C1NC2=C(C=CC(OCCCCN3CCN(C4=C(C=CS5=O)C5=CC=C4)CC3)=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Brexpiprazole S-oxideDM-3411DM3411DM 34115-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorMetaboliteBrexpiprazoleCYP3A45-HT1A5-HT2AInhibitorinhibitorinhibit

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Brexpiprazole S-oxide
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HY-133152
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