1. Others GPCR/G Protein Neuronal Signaling
  2. Isotope-Labeled Compounds 5-HT Receptor Dopamine Receptor
  3. Brexpiprazole S-oxide-d8

Brexpiprazole S-oxide-d8  (Synonyms: DM-3411 d8)

Cat. No.: HY-133152S Purity: 98.72%
COA Handling Instructions

Brexpiprazole S-oxide-d8 is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

For research use only. We do not sell to patients.

Brexpiprazole S-oxide-d<sub>8</sub> Chemical Structure

Brexpiprazole S-oxide-d8 Chemical Structure

CAS No. : 2748605-29-8

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Based on 1 publication(s) in Google Scholar

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Description

Brexpiprazole S-oxide-d8 is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

IC50 & Target[2]

5-HT1A Receptor

0.12 nM (Ki)

5-HT2A Receptor

0.47 nM (Ki)

D2 Receptor

0.3 nM (Ki)

Molecular Weight

457.61

Formula

C25H19D8N3O3S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S1C=CC2=C(N3C([2H])([2H])C([2H])([2H])N(CCCCOC4=CC=C(C=CC(N5)=O)C5=C4)C([2H])([2H])C3([2H])[2H])C=CC=C21

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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Brexpiprazole S-oxide-d8
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