1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor
  3. Brexpiprazole S-oxide D8

Brexpiprazole S-oxide D8 (Synonyms: DM-3411 D8)

Cat. No.: HY-133152S
Handling Instructions

Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM.

For research use only. We do not sell to patients.

Brexpiprazole S-oxide D8 Chemical Structure

Brexpiprazole S-oxide D8 Chemical Structure

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Description

Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

IC50 & Target[2]

5-HT1A Receptor

0.12 nM (Ki)

5-HT2A Receptor

0.47 nM (Ki)

D2 Receptor

0.3 nM (Ki)

Molecular Weight

457.61

Formula

C₂₅H₁₉D₈N₃O₃S

SMILES

O=S1C=CC2=C(N3C([2H])([2H])C([2H])([2H])N(CCCCOC4=CC=C(C=CC(N5)=O)C5=C4)C([2H])([2H])C3([2H])[2H])C=CC=C21

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Brexpiprazole S-oxide D8DM-3411 D85-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorMetabolitedeuteriumlabeledBrexpiprazoleCYP3A45-HT1A5-HT2AInhibitorinhibitorinhibit

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Brexpiprazole S-oxide D8
Cat. No.:
HY-133152S
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