1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Tetrac

Tetrac (Synonyms: Tetraiodothyroacetic acid; 3,3',5,5'-Tetraiodothyroacetic acid)

Cat. No.: HY-W008859
Handling Instructions

Tetrac is a naturally occurring metabolite of L-Thyroxine (T4). Tetrac can specifically block the binding and thyroid hormone action at the integrin receptor, and has anticancer and anti-angiogenic activity.

For research use only. We do not sell to patients.

Tetrac Chemical Structure

Tetrac Chemical Structure

CAS No. : 67-30-1

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tetrac is a naturally occurring metabolite of L-Thyroxine (T4). Tetrac can specifically block the binding and thyroid hormone action at the integrin receptor, and has anticancer and anti-angiogenic activity[1][2].

In Vitro

Tetrac (0.01-1 μM; 2-6 d) induces anti-proliferation in HT-29 and HCT116 cells with different K-RAS status[3].
Tetrac (0.1 μM; 30 min) inhibits activation of ERK1/2 in HT-29 and HCT116 cells[3].
Tetrac (0.1 μM; 24 h) inhibits expression of CCND1 and c-Myc, but promotes expression of CASP2 and THBS1[3].

Cell Proliferation Assay[3]

Cell Line: HT-29 and HCT116 cells
Concentration: 0.01, 0.1, 1 μM
Incubation Time: 0, 2, 4, 6 days
Result: Induced anti-proliferation of K-RAS wild-type colorectal cancer cells.

Western Blot Analysis[3]

Cell Line: HT-29 and HCT116 cells
Concentration: 0.1 μM
Incubation Time: 30 min
Result: Inhibited constitutively activated ERK1/2, and this inhibition can remove by anti-integrin αvβ3 antibody pretreatment.
In Vivo

Tetrac (35 μg; p.o. for 40 days) inhibits tumor inoculation, growth and integrin expression in mice[4].

Animal Model: Wild-type male Balb/C mice aged 8 weeks are inoculated with 102B16F10 or B16LS9 cells[4]
Dosage: 35 μg per day
Administration: P.o. (added to the drinking water) daily for 40 days
Result: Delayed the onset of ocular melanoma.
Reduced the S-100 and integrin staining level in the B16F10 mice model.
Molecular Weight

747.83

Formula

C₁₄H₈I₄O₄

CAS No.

67-30-1

SMILES

O=C(O)CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TetracTetraiodothyroacetic acid 3,3',5,5'-Tetraiodothyroacetic acidEndogenous MetabolitenaturallymetaboliteL-ThyroxineT4integrinanticanceranti-angiogenicInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Tetrac
Cat. No.:
HY-W008859
Quantity:
MCE Japan Authorized Agent: