2. Cytoskeleton
    Metabolic Enzyme/Protease
  3. Integrin
    Endogenous Metabolite
  4. Tetrac

Tetrac  (Synonyms: Tetraiodothyroacetic acid; 3,3',5,5'-Tetraiodothyroacetic acid)

Cat. No.: HY-W008859 Purity: 98.04%
COA Handling Instructions

Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities.

For research use only. We do not sell to patients.

Tetrac Chemical Structure

Tetrac Chemical Structure

CAS No. : 67-30-1

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
25 mg USD 100 In-stock
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Based on 1 publication(s) in Google Scholar

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities[1][2].

In Vitro

Tetrac (0.01-1 μM; 2-6 d) induces anti-proliferation in HT-29 and HCT116 cells with different K-RAS status[3].
Tetrac (0.1 μM; 30 min) inhibits activation of ERK1/2 in HT-29 and HCT116 cells[3].
Tetrac (0.1 μM; 24 h) inhibits expression of CCND1 and c-Myc, but promotes expression of CASP2 and THBS1[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: HT-29 and HCT116 cells
Concentration: 0.01, 0.1, 1 μM
Incubation Time: 0, 2, 4, 6 days
Result: Induced anti-proliferation of K-RAS wild-type colorectal cancer cells.

Western Blot Analysis[3]

Cell Line: HT-29 and HCT116 cells
Concentration: 0.1 μM
Incubation Time: 30 min
Result: Inhibited constitutively activated ERK1/2, and this inhibition can remove by anti-integrin αvβ3 antibody pretreatment.
In Vivo

Tetrac (35 μg; p.o. for 40 days) inhibits tumor inoculation, growth and integrin expression in mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type male Balb/C mice aged 8 weeks are inoculated with 102B16F10 or B16LS9 cells[4]
Dosage: 35 μg per day
Administration: P.o. (added to the drinking water) daily for 40 days
Result: Delayed the onset of ocular melanoma.
Reduced the S-100 and integrin staining level in the B16F10 mice model.
Molecular Weight

747.83

Appearance

Solid

Formula

C14H8I4O4
CAS No.
SMILES

O=C(O)CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (133.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3372 mL 6.6860 mL 13.3720 mL
5 mM 0.2674 mL 1.3372 mL 2.6744 mL
10 mM 0.1337 mL 0.6686 mL 1.3372 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (3.34 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.34 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.34 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Tetrac67-30-1Tetraiodothyroacetic acid 3,3',5,5'-Tetraiodothyroacetic acidIntegrinEndogenous MetabolitenaturallymetaboliteL-ThyroxineT4integrinanticanceranti-angiogenicInhibitorinhibitorinhibit

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