2. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  3. Dopamine Receptor
    Endogenous Metabolite
  4. 3-O-Methyldopa

3-O-Methyldopa  (Synonyms: 3-Methoxy-L-tyrosine; 3-O-Methyl-L-DOPA)

Cat. No.: HY-113468A Purity: ≥98.0%
COA Handling Instructions

3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine.

For research use only. We do not sell to patients.

3-O-Methyldopa Chemical Structure

3-O-Methyldopa Chemical Structure

CAS No. : 300-48-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in Water USD 279 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 279 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine[1].

Clinical Trial
Molecular Weight

211.21

Appearance

Solid

Formula

C10H13NO4
CAS No.
SMILES

N[[email protected]@H](CC1=CC=C(O)C(OC)=C1)C(O)=O
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 16.67 mg/mL (78.93 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7346 mL 23.6731 mL 47.3462 mL
5 mM 0.9469 mL 4.7346 mL 9.4692 mL
10 mM 0.4735 mL 2.3673 mL 4.7346 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (47.35 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

3-O-Methyldopa300-48-13-Methoxy-L-tyrosine 3-O-Methyl-L-DOPADopamine ReceptorEndogenous MetaboliteL-DOPACOMTdopaminedecarboxylaseneurotoxiccompetitivelyInhibitorinhibitorinhibit

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