16-HETE
16-HETE is arachidonic acid metabolite through subterminal hydroxylation by cytochrome P-450. 16-HETE exhibits vasodilatory and PMN inhibitory effects and serves as biomarker for early stages of non-alcoholic fatty liver disease.
For research use only. We do not sell to patients.
- CAS No.: 128914-46-5
- Formula: C20H32O3
- Molecular Weight:320.47
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
16-HETE (0.01-1 μM) specificially suppresses PMN aggregation and adhesion, with no significant effects on platelets function and blood pressure[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
16-HETE (1 μg/kg/min) suppresses the increase of intracranial pressure (ICP) in a rabbit model of thromboembolic stroke[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:New Zealand White rabbit[2]
-
Dosage:1-20 μg
-
Administration:injection into artery
-
Result:16S inhibited 60% ATPase activity at the concentration of 2 μM, while 16R enantiomer remained inactive.
-
Animal Model:New Zealand White rabbit[1]
-
Dosage:1 μg/kg/min
-
Administration:6 hours constant infusion from Hours 1 to 2 after autologous clot embolization
-
Result:Reduced infarction area and less increased ICP.
Chemical Information
-
CAS No. 128914-46-5
-
Molecular Weight 320.47
-
Formula C20H32O3
-
SMILES
CCCCC(O)/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Bednar MM, et al., 16(R)-hydroxyeicosatetraenoic acid, a novel cytochrome P450 product of arachidonic acid, suppresses activation of human polymorphonuclear leukocyte and reduces intracranial pressure in a rabbit model of thromboembolic stroke. Neurosurgery. 2000 Dec;47(6):1410-8; discussion 1418-9. [Content Brief]
[2]. Carroll MA, e al., Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol. 1996 Oct;271(4 Pt 2):R863-9. [Content Brief]
[3]. Maciejewska D, et al., Metabolites of arachidonic acid and linoleic acid in early stages of non-alcoholic fatty liver disease--A pilot study. Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt B):184-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz