1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. all-trans-4-Oxoretinoic acid

all-trans-4-Oxoretinoic acid (Synonyms: all-trans 4-Keto Retinoic Acid)

Cat. No.: HY-107494A
Handling Instructions

all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

For research use only. We do not sell to patients.

all-trans-4-Oxoretinoic acid Chemical Structure

all-trans-4-Oxoretinoic acid Chemical Structure

CAS No. : 38030-57-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 259 In-stock
Estimated Time of Arrival: December 31
2 mg USD 150 In-stock
Estimated Time of Arrival: December 31
5 mg USD 330 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs)[1]. all-trans-4-Oxoretinoic acid is a biologically active geometric isomer of retinoic acid (RA) [2].

Molecular Weight

314.42

Formula

C₂₀H₂₆O₃

CAS No.

38030-57-8

SMILES

CC(/C=C/C=C(/C=C/C1=C(C(CCC(C)1C)=O)C)C)=C\C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (477.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1805 mL 15.9023 mL 31.8046 mL
5 mM 0.6361 mL 3.1805 mL 6.3609 mL
10 mM 0.3180 mL 1.5902 mL 3.1805 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.95 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
all-trans-4-Oxoretinoic acid
Cat. No.:
HY-107494A
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