4-Hydroxyretinoic acid

Cat. No.: HY-125904 Purity: 95.11%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

4-Hydroxyretinoic acid (4-HRA) is a naturally occurring retinoid derivative with diverse biological effects. 4-Hydroxyretinoic acid is formed from retinol catalyzed by cytochrome P-450 isozyme(s), and is mainly metabolized by the liver in the body. 4-Hydroxyretinoic acid also serves as the substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7. 4-Hydroxyretinoic acid regulates gene expression and cell differentiation via binding to nuclear receptor RAR (Retinoic Acid Receptor), and activates RARs and RXR-alpha, to induce cancer cell apoptosis. In addition, 4-Hydroxyretinoic acid is also involved in various physiological processes such as immune regulation, neuroprotection, and anti-oxidation.

For research use only. We do not sell to patients.

4-Hydroxyretinoic acid Chemical Structure

CAS No. : 66592-72-1

Size	Price	Stock	Quantity
1 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 850	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1280	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

UDP-glucuronosyltransferase, cytochrome P-450 isozyme^[1]; RAR, RXR-alpha^[2]

Molecular Weight

316.43

Formula

C₂₀H₂₈O₃

CAS No.

66592-72-1

Appearance

Solid

Color

White to yellow

SMILES

CC(/C=C/C=C(/C=C/C1=C(C(O)CCC(C)1C)C)C)=C\C(O)=O

Shipping

Shipping with dry ice.

Storage

-80°C

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (316.03 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1603 mL	15.8013 mL	31.6026 mL
5 mM	0.6321 mL	3.1603 mL	6.3205 mL
10 mM	0.3160 mL	1.5801 mL	3.1603 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.11%

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Data Sheet (269 KB) SDS (251 KB)

COA (241 KB) HNMR (253 KB) LCMS (84 KB)

Handling Instructions (2659 KB)

References

[1]. Samokyszyn VM, et al. 4-hydroxyretinoic acid, a novel substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7. J Biol Chem. 2000 Mar 10;275(10):6908-14. [Content Brief]

[2]. Duell EA, et al. Human skin levels of retinoic acid and cytochrome P-450-derived 4-hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor-mediated transcription in vitro. J Clin Invest. 1992 Oct;90(4):1269-74. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1603 mL	15.8013 mL	31.6026 mL	79.0064 mL
	5 mM	0.6321 mL	3.1603 mL	6.3205 mL	15.8013 mL
	10 mM	0.3160 mL	1.5801 mL	3.1603 mL	7.9006 mL
	15 mM	0.2107 mL	1.0534 mL	2.1068 mL	5.2671 mL
	20 mM	0.1580 mL	0.7901 mL	1.5801 mL	3.9503 mL
	25 mM	0.1264 mL	0.6321 mL	1.2641 mL	3.1603 mL
	30 mM	0.1053 mL	0.5267 mL	1.0534 mL	2.6335 mL
	40 mM	0.0790 mL	0.3950 mL	0.7901 mL	1.9752 mL
	50 mM	0.0632 mL	0.3160 mL	0.6321 mL	1.5801 mL
	60 mM	0.0527 mL	0.2634 mL	0.5267 mL	1.3168 mL
	80 mM	0.0395 mL	0.1975 mL	0.3950 mL	0.9876 mL
	100 mM	0.0316 mL	0.1580 mL	0.3160 mL	0.7901 mL