1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. (Rac)-5-Hydroxymethyl Tolterodine hydrochloride

(Rac)-5-Hydroxymethyl Tolterodine hydrochloride (Synonyms: (Rac)-Desfesoterodine hydrochloride; (Rac)-PNU-200577 hydrochloride)

Cat. No.: HY-76570A
Handling Instructions

(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) hydrochloride, an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine hydrochloride can be used for overactive bladder research.

For research use only. We do not sell to patients.

(Rac)-5-Hydroxymethyl Tolterodine hydrochloride Chemical Structure

(Rac)-5-Hydroxymethyl Tolterodine hydrochloride Chemical Structure

CAS No. : 250214-40-5

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Description

(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) hydrochloride, an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine hydrochloride can be used for overactive bladder research[1].

IC50 & Target

Ki: M1 (2.3 nM), M2 (2 nM), M3 (2.5 nM), M4 (2.8 nM), and M5 (2.9 nM)[1]

In Vitro

In vitro, (Rac)-5-Hydroxymethyl Tolterodine (PNU-200577) hydrochloride produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips (KB of 0.84 nM; pA2 of 9.14)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(Rac)-5-Hydroxymethyl Tolterodine (5-HMT; 0.88 μmol/kg; i.v.) hydrochloride treatment shows the binding activity of (Rac)-5-Hydroxymethyl Tolterodine hydrochloride to muscarinic receptors is significantly observed in all tissues, except cerebral cortex, with a longer duration in bladder[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

377.95

Formula

C₂₂H₃₂ClNO₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride
Cat. No.:
HY-76570A
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