1. Membrane Transporter/Ion Channel
    Anti-infection
  2. CRM1
    HIV
  3. Leptomycin A

Leptomycin A 

Cat. No.: HY-N6795
Handling Instructions

Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B.

For research use only. We do not sell to patients.

Leptomycin A Chemical Structure

Leptomycin A Chemical Structure

CAS No. : 87081-36-5

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Description

Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B[1][2].

IC50 & Target

CRM1[1][2].

Molecular Weight

526.70

Formula

C₃₂H₄₆O₆

CAS No.

87081-36-5

SMILES

O=C(O)/C=C(C)/C[[email protected]](C)[[email protected]@H](O)[[email protected]](C)C([[email protected]](C)/C=C(C)/C=C/C[[email protected]@H](C)/C=C(C)\C=C\[[email protected]]1[[email protected]@H](C)C=CC(O1)=O)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Leptomycin A
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