2. Membrane Transporter/Ion Channel Anti-infection
  3. CRM1 HIV Antibiotic
  4. Leptomycin A

Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B.

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Leptomycin A Chemical Structure

Leptomycin A Chemical Structure

CAS No. : 87081-36-5

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Description

Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B[1][2].

IC50 & Target

HIV-1

 

Molecular Weight

526.70

Formula

C32H46O6
CAS No.
Appearance

Solid

Color

Colorless to light yellow

SMILES

O=C(O)/C=C(C)/C[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)/C=C(C)/C=C/C[C@@H](C)/C=C(C)\C=C\[C@H]1[C@@H](C)C=CC(O1)=O)=O
Structure Classification
Initial Source

Streptomyces
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

COA (243 KB)

Handling Instructions (2659 KB)
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Leptomycin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leptomycin A87081-36-5CRM1HIVAntibioticChromosomal Maintenance 1Exportin 1XPO1Human immunodeficiency virusInhibitorinhibitorinhibit

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