Itaconic acid (Synonyms: Methylenesuccinic acid)

Cat. No.: HY-Y0520 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect.

For research use only. We do not sell to patients.

Itaconic acid Chemical Structure

CAS No. : 97-65-4

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 73	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 73	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 66	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of Itaconic acid:

Itaconic acid-¹³C₅ In-stock

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Biological Activity
Purity & Documentation
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Description

In Vitro

Itaconic acid (2–8 mM, 24 h) induces ferroptosis by activating ferritinophagy in PANC1 cells^[3].
Itaconic acid (10 mM, 24 h) inhibits LPS-induced inflammatory cytokines in RAW264.7 cells^[4].
Itaconic acid (10 mM, 24 h) promotes the pentose phosphate pathway (PPP) and NADPH oxidase activity in RAW264.7 cells^[4].
Itaconic acid (10 mM, 24-72 h) inhibits cell viability of cerebellar granule cells (CGC) and inhibits ADP-stimulated respiration in permeabilized CGC cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

130.10

Formula

C₅H₆O₄

CAS No.

97-65-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(CC(O)=O)=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 27.78 mg/mL (213.53 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.6864 mL	38.4320 mL	76.8639 mL
5 mM	1.5373 mL	7.6864 mL	15.3728 mL
10 mM	0.7686 mL	3.8432 mL	7.6864 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 25 mg/mL (192.16 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (271 KB) SDS (416 KB)

COA (244 KB) HNMR (229 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	7.6864 mL	38.4320 mL	76.8639 mL	192.1599 mL
	5 mM	1.5373 mL	7.6864 mL	15.3728 mL	38.4320 mL
	10 mM	0.7686 mL	3.8432 mL	7.6864 mL	19.2160 mL
	15 mM	0.5124 mL	2.5621 mL	5.1243 mL	12.8107 mL
	20 mM	0.3843 mL	1.9216 mL	3.8432 mL	9.6080 mL
	25 mM	0.3075 mL	1.5373 mL	3.0746 mL	7.6864 mL
	30 mM	0.2562 mL	1.2811 mL	2.5621 mL	6.4053 mL
	40 mM	0.1922 mL	0.9608 mL	1.9216 mL	4.8040 mL
	50 mM	0.1537 mL	0.7686 mL	1.5373 mL	3.8432 mL
	60 mM	0.1281 mL	0.6405 mL	1.2811 mL	3.2027 mL
	80 mM	0.0961 mL	0.4804 mL	0.9608 mL	2.4020 mL
	100 mM	0.0769 mL	0.3843 mL	0.7686 mL	1.9216 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Itaconic acid97-65-4Methylenesuccinic acidInhibitorinhibitorinhibit

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