Siamycin I
Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a HIV fusion inhibitor with ED50s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research.
For research use only. We do not sell to patients.
- CAS No.: 164802-68-0
- Formula: C97H131N23O26S4
- Molecular Weight:2163.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Antibiotic Isoforms
More
Biological Activity
|
HIV-1 |
HIV-2 |
Siamycin I slightly inhibits the growth of E. faecalis at a concentration of 1 μM (80% growth 5 h after inoculation) and completely inhibits the growth at a concentration of 5 μM (no growth 12 h after inoculation)[3].
siamycin I (0-1 μM; 24 h) slightly inhibits biofilm formation at a concentration of 0.25 μM, and the inhibitory effect is marked at concentrations higher than 0.5 μM[3].
Siamycin I inhibits fusion between C8166 cells and CEM-SS cells chronically infected with HIV (ED50=0.08 μM) but has no effect on Sendai virus-induced fusion or murine myoblast fusion[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 164802-68-0
-
Molecular Weight 2163.48
-
Formula C97H131N23O26S4
-
Synonyms
BMY-29304
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Pikyee Ma, et al. Anti-HIV siamycin I directly inhibits autophosphorylation activity of the bacterial FsrC quorum sensor and other ATP-dependent enzyme activities. FEBS Lett. 2011 Sep 2;585(17):2660-4. [Content Brief]
[2]. Stephanie Tan, et al. The Lasso Peptide Siamycin-I Targets Lipid II at the Gram-Positive Cell Surface. ACS Chem Biol. 2019 May 17;14(5):966-974. [Content Brief]
[3]. Jiro Nakayama, et al. Siamycin attenuates fsr quorum sensing mediated by a gelatinase biosynthesis-activating pheromone in Enterococcus faecalis. J Bacteriol. 2007 Feb;189(4):1358-65. [Content Brief]
[4]. M Tsunakawa, et al. Siamycins I and II, new anti-HIV peptides: I. Fermentation, isolation, biological activity and initial characterization. J Antibiot (Tokyo). 1995 May;48(5):433-4. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Siamycin I Related Classifications
HY-P2200 Related Classifications
Powered by Bioz