1. Metabolic Enzyme/Protease
  2. Drug Metabolite Endogenous Metabolite Angiotensin-converting Enzyme (ACE)
  3. Benazeprilat

Benazeprilat  (Synonyms: CGS 14831)

Cat. No.: HY-118472 Purity: ≥99.0%
COA Handling Instructions

Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage.

For research use only. We do not sell to patients.

Benazeprilat Chemical Structure

Benazeprilat Chemical Structure

CAS No. : 86541-78-8

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Based on 1 publication(s) in Google Scholar

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Description

Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage[1][2][3].

In Vivo

Benazeprilat (10 mg/kg, intravenous injection) and amlodipine (0.5 mg/kg, intravenous injection) in combination produce great hypotensive effect[2].
Benazepril (0.7 mg/kg, oral) markedly influences the dynamics of systemic RAAS peptides, resulting in a substantial decrease in AII and ALD while increasing PRA and AI[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SHR (14-16 weeks of age, 250-350 g)[2].
Dosage: 10 mg/kg
Administration: I.V; once a day for 2 days.
Result: Produced hypotensive effect.
Animal Model: Beagle dogs (12.0-19.5 kg)[3].
Dosage: 0.7 mg/kg
Administration: P.O, once a day for 5 days.
Result: Effected systemic RAAS peptides.
Molecular Weight

396.44

Formula

C22H24N2O5

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@H](CCC2=C(C=CC=C2)N1CC(O)=O)N([C@@H](CCC3=CC=CC=C3)C(O)=O)[H]

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Benazeprilat
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