6-Phosphogluconic acid trisodium

Name: 6-Phosphogluconic acid trisodium
Brand: MedChemExpress
SKU: HY-W011184
Rating: 4.5 (1 reviews)

Cat. No.: HY-W011184 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with K_is of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite.

For research use only. We do not sell to patients.

6-Phosphogluconic acid trisodium Chemical Structure

CAS No. : 53411-70-4

Size	Price	Stock	Quantity
5 mg	USD 35	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 107	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 6-Phosphogluconic acid trisodium:

6-Phosphogluconic acid Get quote

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

phosphoglucose isomerase^[1]

In Vitro

6-Phosphogluconic acid trisodium (0.5-2.0 mM) completely inhibits the activity of PGI with glucose 6-phosphate (0.05- 0.5 mM) as the substrate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

342.08

Formula

C₆H₁₀Na₃O₁₀P

CAS No.

53411-70-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O[Na])(O[Na])=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (365.41 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9233 mL	14.6165 mL	29.2329 mL
5 mM	0.5847 mL	2.9233 mL	5.8466 mL
10 mM	0.2923 mL	1.4616 mL	2.9233 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (273 KB) SDS (418 KB)

COA (249 KB) HNMR (256 KB) CNMR (330 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52. [Content Brief]

[2]. Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.9233 mL	14.6165 mL	29.2329 mL	73.0823 mL
	5 mM	0.5847 mL	2.9233 mL	5.8466 mL	14.6165 mL
	10 mM	0.2923 mL	1.4616 mL	2.9233 mL	7.3082 mL
	15 mM	0.1949 mL	0.9744 mL	1.9489 mL	4.8722 mL
	20 mM	0.1462 mL	0.7308 mL	1.4616 mL	3.6541 mL
	25 mM	0.1169 mL	0.5847 mL	1.1693 mL	2.9233 mL
	30 mM	0.0974 mL	0.4872 mL	0.9744 mL	2.4361 mL
	40 mM	0.0731 mL	0.3654 mL	0.7308 mL	1.8271 mL
	50 mM	0.0585 mL	0.2923 mL	0.5847 mL	1.4616 mL
	60 mM	0.0487 mL	0.2436 mL	0.4872 mL	1.2180 mL
	80 mM	0.0365 mL	0.1827 mL	0.3654 mL	0.9135 mL
	100 mM	0.0292 mL	0.1462 mL	0.2923 mL	0.7308 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.