4-Pentenoic acid
Based on 1 Customer Validation
4-Pentenoic acid is a medium-chain unsaturated fatty acid. 4-Pentenoic acid has hypoglycemic and fatty acid oxidation inhibitory activities. 4-Pentenoic acid can affect blood glucose metabolism and energy metabolism through mechanisms such as inhibiting long-chain fatty acid oxidation, reducing gluconeogenesis, and promoting glucose utilization.
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- Purity : 99.92%
- CAS No.: 591-80-0
- 화학식: C5H8O2
- 분자량:100.12
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보관:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
제품 설명
In Vitro
4-Pentenoic acid (0.1 mM; 20-170 s) can significantly inhibit thiolase in rat heart mitochondria[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male white mice (20-25g)[2]
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Dosage:7.5 and 15 mg
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Administration:Intraperitoneal injection; single dose
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Result:Led to a decrease in blood glucose levels, with the maximum decrease at 30 minutes.
Inhibited palmitate oxidation in myocardial homogenates.
Increased incorporation of labeled palmitate into the liver.
Inhibited gluconeogenesis, and enhanced glucose oxidation.
Chemical Information
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CAS No. 591-80-0
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Appearance Liquid (Density: 0.981 g/cm3)
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분자량 100.12
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화학식 C5H8O2
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Color Colorless to light yellow
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SMILES
C=CCCC(O)=O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 100 mg/mL (998.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 65 mg/mL (649.22 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (276 KB)
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SDS (615 KB)
- English - EN (615 KB)
- Français - FR (615 KB)
- Deutsch - DE (615 KB)
- Norwegian - NO (615 KB)
- Español - ES (615 KB)
- Swedish - SV (615 KB)
- Italian - IT (615 KB)
- Korean - KR (615 KB)
- Portuguese - PT (615 KB)
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Handling Instructions (2659 KB)
References
[1]. Schulz H, et al. [48] 4-Pentenoic acid[M]//Methods in enzymology. Academic Press, 1981, 72: 604-610.
[2]. Corredor C, et al. Studies of the mechanism of the hypoglycemic action of 4-pentenoic acid. Proc Natl Acad Sci U S A. 1967 Dec;58(6):2299-306. [Content Brief]
[3]. Schulz H. Metabolism of 4-pentenoic acid and inhibition of thiolase by metabolites of 4-pentenoic acid. Biochemistry. 1983 Apr 12;22(8):1827-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 9.9880 mL | 49.9401 mL | 99.8801 mL | 249.7004 mL |
| 5 mM | 1.9976 mL | 9.9880 mL | 19.9760 mL | 49.9401 mL | |
| 10 mM | 0.9988 mL | 4.9940 mL | 9.9880 mL | 24.9700 mL | |
| 15 mM | 0.6659 mL | 3.3293 mL | 6.6587 mL | 16.6467 mL | |
| 20 mM | 0.4994 mL | 2.4970 mL | 4.9940 mL | 12.4850 mL | |
| 25 mM | 0.3995 mL | 1.9976 mL | 3.9952 mL | 9.9880 mL | |
| 30 mM | 0.3329 mL | 1.6647 mL | 3.3293 mL | 8.3233 mL | |
| 40 mM | 0.2497 mL | 1.2485 mL | 2.4970 mL | 6.2425 mL | |
| 50 mM | 0.1998 mL | 0.9988 mL | 1.9976 mL | 4.9940 mL | |
| 60 mM | 0.1665 mL | 0.8323 mL | 1.6647 mL | 4.1617 mL | |
| 80 mM | 0.1249 mL | 0.6243 mL | 1.2485 mL | 3.1213 mL | |
| 100 mM | 0.0999 mL | 0.4994 mL | 0.9988 mL | 2.4970 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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