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Ezutromid (Synonyms: SMT C1100; BMN 195; VOX-C1100)

Cat. No.: HY-17614 Purity: 99.12%
Handling Instructions

Ezutromid is a novel Small utrophin's translation modulator with EC50 of 0.4 uM .

For research use only. We do not sell to patients.

Ezutromid Chemical Structure

Ezutromid Chemical Structure

CAS No. : 945531-77-1

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 624 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1056 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Ezutromid is a novel Small utrophin's translation modulator with EC50 of 0.4 uM . In vitro: 1) SMT C1100 induces increased levels of utrophin RNA in human muscle cells. 2) Treatment of human DMD cells with SMT C1100 lead to a 2-fold increase in utrophin protein levels at an optimal concentration of 0.3 uM after 3 days of treatment. 3) SMT C1100 wassafe and well tolerated with plasma concentrations achieved suf cient to cause a 50% increase in concentrations of utrophin in cells. 4) SMT C1100 led to a 30% increase in Utrn mRNA level and resulted in a 2.0-fold increase in UTRN protein level . In vivo: 1)The reference for administration is 50 mg/kg. 2) it was considered that no toxicity was determined for SMT C1100 administered by oral gavage to the mouse up to dose levels of 2000 mg/kg/day for 28 days. Note: You can dissolve the products in phosphate buffered saline (PBS), 0.1% Tween-20, 5% DMSO)

Clinical Trial
Molecular Weight

337.39

Formula

C₁₉H₁₅NO₃S

CAS No.

945531-77-1

SMILES

O=S(C1=CC=C(OC(C2=CC=C3C=CC=CC3=C2)=N4)C4=C1)(CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (29.64 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9639 mL 14.8196 mL 29.6393 mL
5 mM 0.5928 mL 2.9639 mL 5.9279 mL
10 mM 0.2964 mL 1.4820 mL 2.9639 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Ezutromid
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HY-17614
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