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Ezutromid (Synonyms: SMT C1100; BMN 195; VOX-C1100)

Cat. No.: HY-17614 Purity: 99.12%
Handling Instructions

Ezutromid (SMT C1100) is a first-in-class, orally active benzoxazole utrophin modulator with an EC50 of 0.91 μM. Ezutromid can be used for the research Duchenne muscular dystrophy (DMD). Ezutromid inhibits CYP1A2 enzymic activity in human liver microsomes (HLM) with an IC50 of 5.4 μM.

For research use only. We do not sell to patients.

Ezutromid Chemical Structure

Ezutromid Chemical Structure

CAS No. : 945531-77-1

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10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
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10 mg USD 180 In-stock
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50 mg USD 624 In-stock
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100 mg USD 1056 In-stock
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Description

Ezutromid (SMT C1100) is a first-in-class, orally active benzoxazole utrophin modulator with an EC50 of 0.91 μM. Ezutromid can be used for the research Duchenne muscular dystrophy (DMD). Ezutromid inhibits CYP1A2 enzymic activity in human liver microsomes (HLM) with an IC50 of 5.4 μM[1][2].

In Vitro

Ezutromid induces increased levels of utrophin RNA in human muscle cells. Treatment of human DMD cells with Ezutromid lead to a 2-fold increase in utrophin protein levels at an optimal concentration of 0.3 uM after 3 days of treatment. Ezutromid was safe and well tolerated with plasma concentrations achieved suf cient to cause a 50% increase in concentrations of utrophin in cells. Ezutromid led to a 30% increase in Utrn mRNA level and resulted in a 2.0-fold increase in UTRN protein level[3][4][5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Note: You can dissolve the products in phosphate buffered saline (PBS), 0.1% Tween-20, 5% DMSO)

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

337.39

Formula

C₁₉H₁₅NO₃S

CAS No.

945531-77-1

SMILES

O=S(C1=CC=C(OC(C2=CC=C3C=CC=CC3=C2)=N4)C4=C1)(CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (29.64 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9639 mL 14.8196 mL 29.6393 mL
5 mM 0.5928 mL 2.9639 mL 5.9279 mL
10 mM 0.2964 mL 1.4820 mL 2.9639 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

EzutromidSMT C1100 BMN 195 VOX-C1100SMT C 1100SMT C-1100BMN195BMN 195BMN-195OthersbenzoxazoleDuchennemusculardystrophylivermicrosomesmetaboliteInhibitorinhibitorinhibit

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