(20R)-Protopanaxadiol

Cat. No.: HY-N2040 Purity: 99.82%: FAQs
Data Sheet SDS COA Handling Instructions

(20R)-Protopanaxadiol is a triterpenoid saponin metabolite of 20(R)-ginsenoside Rg3 in black ginseng. (20R)-Protopanaxadiol exhibits anti-tumor activity and cytotoxicity, and potently inhibits the growth of Helicobacter pylori.

For research use only. We do not sell to patients.

(20R)-Protopanaxadiol Chemical Structure

CAS No. : 7755-01-3

Size	Price	Stock	Quantity
Solution
10 mM * 1 mL in DMSO	USD 122	In-stock	Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL ready for reconstitution	USD 122	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

460.73

Appearance

Solid

Formula

C₃₀H₅₂O₃

CAS No.

7755-01-3

SMILES

C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O)C)(CC[C@@]2([H])C3(C)C)[C@]4([C@@]1([H])[C@]([C@](C)(O)CC/C=C(C)/C)([H])CC4)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (43.41 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1705 mL	10.8523 mL	21.7047 mL
5 mM	0.4341 mL	2.1705 mL	4.3409 mL
10 mM	0.2170 mL	1.0852 mL	2.1705 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: 2 mg/mL (4.34 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: 2 mg/mL (4.34 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 2 mg/mL (4.34 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (250 KB) HNMR (152 KB) RP-HPLC (134 KB)

Handling Instructions (2659 KB)

References

[1]. Liu L, et al. Enzymatic preparation of 20(S, R)-protopanaxadiol by transformation of 20(S, R)-Rg3 from black ginseng. Phytochemistry. 2010 Sep;71(13):1514-20. [Content Brief]

[2]. Bae EA, et al. Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol Pharm Bull. 2002 Jan;25(1):58-63. [Content Brief]

[3]. Hasegawa H, et al. Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Planta Med. 1994 Jun;60(3):240-3. [Content Brief]