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Cat. No.: HY-145513

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CL2-MMT-SN38

CL2-MMT-SN38 is a SN-38 derivative. SN-38, an anticancer agent, is an active metabolite of the Topoisomerase I inhibitor Irinotecan (CPT-11).

For research use only. We do not sell to patients.

CAS No.: 1084888-82-3
Formula: C₁₀₂H₁₂₂N₁₂O₂₄
Molecular Weight:1900.13

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CL2-MMT-SN38 Chemical Structure

CAS No.: 1084888-82-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

CL2-MMT-SN38 is a SN-38 derivative. SN-38, an anticancer agent, is an active metabolite of the Topoisomerase I inhibitor Irinotecan (CPT-11)^[1].

All Topoisomerase Isoforms :

Chemical Information

CAS No. 1084888-82-3
Molecular Weight 1900.13
Formula C₁₀₂H₁₂₂N₁₂O₂₄
SMILES

O=C(C1CCC(CC1)CN2C(C=CC2=O)=O)NCC(N=N3)=CN3CCOCCOCCOCCOCCOCCOCCOCCOCCNC(COCC(N[C@@H](CC4=CC=CC=C4)C(N[C@H](C(NC5=CC=C(C=C5)COC(O[C@]6(C7=C(COC6=O)C(N8C(C(C(C8)=C(C9=C%10)CC)=NC9=CC=C%10O)=C7)=O)CC)=O)=O)CCCCNC(C%11=CC=CC=C%11)(C%12=CC=CC=C%12)C%13=CC=C(C=C%13)OC)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Moon SJ, et al. Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy. J Med Chem. 2008;51(21):6916-6926. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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