1. Apoptosis
  2. TNF Receptor
  3. DCVC

DCVC (Synonyms: S-[(1E)-1,2-dichloroethenyl]--L-cysteine)

Cat. No.: HY-19717 Purity: 99.89%
Handling Instructions

DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures.

For research use only. We do not sell to patients.

DCVC Chemical Structure

DCVC Chemical Structure

CAS No. : 13419-46-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures[1][2].

In Vitro

Extraplacental membranes are cultured for 4, 8, and 24h with the trichloroethylene (TCE) metabolite S-(1,2-dichlorovinyl)-l-cysteine (DCVC) in the absence or presence of lipoteichoic acid (LTA) or lipopolysaccharide (LPS) to simulate infection. In addition, membranes were cocultured with DCVC and Group B Streptococcus (GBS). DCVC (5-50μM) significantly inhibited LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4h. DCVC inhibits pathogen-stimulated cytokine (IL-1β, IL-8, and TNF-α) release in a concentration-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

216.09

Formula

C₅H₇Cl₂NO₂S

CAS No.

13419-46-0

SMILES

N[[email protected]](C(O)=O)CS/C(Cl)=C\Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2.5 mg/mL (11.57 mM; Need ultrasonic)

H2O : 1.034 mg/mL (4.79 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6277 mL 23.1385 mL 46.2770 mL
5 mM 0.9255 mL 4.6277 mL 9.2554 mL
10 mM 0.4628 mL 2.3139 mL 4.6277 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.89%

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Keywords:

DCVCS-[(1E)-1,2-dichloroethenyl]--L-cysteineTNF ReceptorTumor Necrosis Factor ReceptorTNFRExtraplacentalmembranestrichloroethyleneimmuneIL-1βIL-8 TNF-αnephrotoxicantInhibitorinhibitorinhibit

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