13419-46-0
13419-46-0
Chemical Structure
DCVC
Synonym(s): S-[(1E)-1,2-Dichloroethenyl]-L-cysteine
- CAS 番号: 13419-46-0
- Formula:C5H7Cl2NO2S
- Molecular Weight:216.09
IUPAC Name: (E)-S-(1,2-dichlorovinyl)-L-cysteine
InChIKey: PJIHCWJOTSJIPQ-PEQLYWQKSA-N
SMILES: N[C@H](C(O)=O)CS/C(Cl)=C\Cl
Biological Activity: DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures[1][2].
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DCVC | 99.78% | DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures. | ||||||||||||||||||||
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DCVC-13C3,15N | DCVC-13C3,15N is 15N and 13C labeled DCVC. DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures. | |||||||||||||||||||||
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References
- [1]. Boldenow E, et al. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α in human extraplacental membranes in vitro. Reprod Toxicol. 2015 Apr;52:1-6. [Content Brief]
- [2]. Lash LH, et al. Multigenerational study of chemically induced cytotoxicity and proliferation in cultures of human proximal tubular cells. Int J Mol Sci. 2014 Nov 18;15(11):21348-65. [Content Brief]
