AT-9010 tetrasodium

Name: AT-9010 tetrasodium
Brand: MedChemExpress
SKU: HY-139165A
Rating: 4.5 (1 reviews)

Cat. No.: HY-139165A Purity: 99.74%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

AT-9010 tetrasodium, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 tetrasodium can inhibit SARS-CoV-2 replication.

For research use only. We do not sell to patients.

AT-9010 tetrasodium Chemical Structure

CAS No. : 1621884-18-1

Size	Price	Stock	Quantity
1 mg	USD 1080	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 2650	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 4000	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of AT-9010 tetrasodium:

AT-9010 Get quote
AT-9010 triethylamine Get quote

1 Publications Citing Use of MCE AT-9010 tetrasodium

•Cell. 2022 Nov 10;185(23):4347-4360.e17. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

NiRAN^[1]

In Vitro

Substantial levels of the active triphosphate metabolite AT-9010 are formed in normal human bronchial and nasal epithelial cells incubated with 10 µM AT-511 (698 µM and 236 µM, respectively), with a half-life of at least 38 hours^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

627.13

Formula

C₁₁H₁₃FN₅Na₄O₁₃P₃

CAS No.

1621884-18-1

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@](F)(C)[C@H](N2C3=C(C(N=C(N3)N)=O)N=C2)O[C@@H]1COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O

Shipping

Shipping with dry ice.

Storage

-80°C, protect from light, stored under nitrogen

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (159.46 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5946 mL	7.9728 mL	15.9457 mL
5 mM	0.3189 mL	1.5946 mL	3.1891 mL
10 mM	0.1595 mL	0.7973 mL	1.5946 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (159.46 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.74%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (250 KB) HNMR (367 KB) LCMS (106 KB)

Handling Instructions (2659 KB)

References

[1]. Atea Pharmaceuticals Announces Publication of Preclinical Data Highlighting Potent Activity of AT-527 Against SARS-CoV-2. BOSTON, Feb. 08, 2021. Atea Pharmaceuticals, Inc.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.5946 mL	7.9728 mL	15.9457 mL	39.8641 mL
	5 mM	0.3189 mL	1.5946 mL	3.1891 mL	7.9728 mL
	10 mM	0.1595 mL	0.7973 mL	1.5946 mL	3.9864 mL
	15 mM	0.1063 mL	0.5315 mL	1.0630 mL	2.6576 mL
	20 mM	0.0797 mL	0.3986 mL	0.7973 mL	1.9932 mL
	25 mM	0.0638 mL	0.3189 mL	0.6378 mL	1.5946 mL
	30 mM	0.0532 mL	0.2658 mL	0.5315 mL	1.3288 mL
	40 mM	0.0399 mL	0.1993 mL	0.3986 mL	0.9966 mL
	50 mM	0.0319 mL	0.1595 mL	0.3189 mL	0.7973 mL
	60 mM	0.0266 mL	0.1329 mL	0.2658 mL	0.6644 mL
	80 mM	0.0199 mL	0.0997 mL	0.1993 mL	0.4983 mL
	100 mM	0.0159 mL	0.0797 mL	0.1595 mL	0.3986 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.