R-(+)-Cotinine (Synonyms: (+)-Cotinine; (R)-Cotinine; (R)-NIH-10498)

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R-(+)-Cotinine ((+)-Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R-(+)-Cotinine can enhance the Ach-evoked current in human α7 nAChRs.

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R-(+)-Cotinine Chemical Structure

CAS No. : 32162-64-4

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Other Forms of R-(+)-Cotinine:

Cotinine In-stock
(Rac)-Cotinine-d₃ In-stock

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Description	R-(+)-Cotinine ((+)-Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R-(+)-Cotinine can enhance the Ach-evoked current in human α7 nAChRs^[1].
In Vitro	R-(+)-Cotinine (1 μM) significantly enhances the Ach (40 μM)-evoked current in human α7 nAChRs^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. R-(+)-Cotinine Related Antibodies
In Vivo	R-(+)-Cotinine (0.3-10 mg/kg; a single i.p.) enhances the effects of a subthreshold dose of Donepezil (0.5 mg/kg) on novel object recognition (NOR) performance^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	176.22
Formula	C₁₀H₁₂N₂O
CAS No.	32162-64-4
SMILES	O=C1N(C)[C@@H](C2=CC=CN=C2)CC1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (272 KB) Handling Instructions (2659 KB)
References	[1]. Jr AVT, et, al. R-(+) and S-(-) isomers of cotinine augment cholinergic responses in vitro and in vivo. J Pharmacol Exp Ther. 2015 Feb;352(2):405-18. [Content Brief]

R-(+)-Cotinine Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R-(+)-Cotinine32162-64-4(+)-Cotinine (R)-Cotinine (R)-NIH-10498nAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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R-(+)-Cotinine (Synonyms: (+)-Cotinine; (R)-Cotinine; (R)-NIH-10498)

Other Forms of R-(+)-Cotinine:

R-(+)-Cotinine Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review