1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker
  3. Phenylacetic acid mustard

Phenylacetic acid mustard 

Cat. No.: HY-136327
Handling Instructions

Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating agent with antitumor activity.

For research use only. We do not sell to patients.

Phenylacetic acid mustard Chemical Structure

Phenylacetic acid mustard Chemical Structure

CAS No. : 10477-72-2

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating agent with antitumor activity[1].

IC50 & Target

IC50: metabolite of Chlorambucil[1]

In Vivo

Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; 15 days) shows consistently 1.8-1.9 times greater antitumour potency than CHL, it exhibits an ED15 value of 8.0 mg/kg[2].
Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; single dose) cause 50% lethality at the dose 15.9 mg/kg[2].

Animal Model: Inbred male C3H/He mice[1]
Dosage: 0 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg
Administration: Intraperitoneal injection; 15 days
Result: Exhibited anti-tumor activities in vivo.
Molecular Weight

276.16

Formula

C₁₂H₁₅Cl₂NO₂

CAS No.

10477-72-2

SMILES

O=C(O)CC1=CC=C(N(CCCl)CCCl)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vivo:
  • 1.

    Phenylacetic acid mustard (PAAM) is dissolved in acidified ethanol (4.8 ml cone HC1 and 95% v/v ethyl alcohol in a volume of 100 ml) and diluted 1:9 with propylene glycol/K2HPO 4 buffer (20 g K2HPO4 plus 450 ml propylene glycol), final pH 7.4[2].

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Phenylacetic acid mustardDNA Alkylator/CrosslinkerchemotherapeuticagentmetaboliteantitumorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Phenylacetic acid mustard
Cat. No.:
HY-136327
Quantity:
MCE Japan Authorized Agent: