1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. LPL Receptor
    Drug Metabolite
  3. RP101988

RP101988 

Cat. No.: HY-136578
Handling Instructions

RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely.

For research use only. We do not sell to patients.

RP101988 Chemical Structure

RP101988 Chemical Structure

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Description

RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely[1].

IC50 & Target[1]

S1PR1

0.19 nM (EC50)

S1PR5

32.8 nM (EC50)

In Vitro

RP101988 is a substrate of P-gp and breast cancer resistance protein (BCRP) drug transporters[2].

Molecular Weight

418.45

Formula

C₂₃H₂₂N₄O₄

SMILES

O=C(O)CN[[email protected]]1CCC2=C1C=CC=C2C3=NOC(C4=CC=C(OC(C)C)C(C#N)=C4)=N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

RP101988RP 101988RP-101988LPL ReceptorDrug MetaboliteLysophospholipid ReceptorselectiveulcerativecolitismetabolitebreastcancersubstrateInhibitorinhibitorinhibit

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RP101988
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HY-136578
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