2. GPCR/G Protein
    Metabolic Enzyme/Protease
  3. LPL Receptor
    Drug Metabolite
  4. RP101988

RP101988 

Cat. No.: HY-136578 Purity: 98.92%
COA Handling Instructions

RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely.

For research use only. We do not sell to patients.

RP101988 Chemical Structure

RP101988 Chemical Structure

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 440 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 440 In-stock
Solid
5 mg USD 400 In-stock
10 mg USD 680 In-stock
25 mg USD 1350 In-stock
50 mg USD 2200 In-stock
100 mg USD 3400 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely[1].

IC50 & Target[1]

S1PR1

0.19 nM (EC50)

S1PR5

32.8 nM (EC50)

In Vitro

RP101988 is a substrate of P-gp and breast cancer resistance protein (BCRP) drug transporters[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

418.45

Appearance

Solid

Formula

C23H22N4O4
SMILES

O=C(O)CN[[email protected]]1CCC2=C1C=CC=C2C3=NOC(C4=CC=C(OC(C)C)C(C#N)=C4)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (298.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3898 mL 11.9489 mL 23.8977 mL
5 mM 0.4780 mL 2.3898 mL 4.7795 mL
10 mM 0.2390 mL 1.1949 mL 2.3898 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

RP101988RP 101988RP-101988LPL ReceptorDrug MetaboliteLysophospholipid ReceptorselectiveulcerativecolitismetabolitebreastcancersubstrateInhibitorinhibitorinhibit

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