2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. MTIC

MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity .

For research use only. We do not sell to patients.

MTIC Chemical Structure

MTIC Chemical Structure

CAS No. : 3413-72-7

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Based on 1 publication(s) in Google Scholar

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MTIC Related Antibodies

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Description

MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity [1][2][3][4].

In Vivo

MTIC (cumulative dose=890 mg/rat/14 wk) can induce a high incidence of breast adenofibroma and a low incidence of uterine leiomyosarcoma[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

168.16

Formula

C5H8N6O
CAS No.
Appearance

Solid

Color

Brown to orange

SMILES

O=C(C1=C(/N=N/NC)N=CN1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (148.67 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9467 mL 29.7336 mL 59.4672 mL
5 mM 1.1893 mL 5.9467 mL 11.8934 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.9467 mL 29.7336 mL 59.4672 mL 148.6679 mL
5 mM 1.1893 mL 5.9467 mL 11.8934 mL 29.7336 mL
10 mM 0.5947 mL 2.9734 mL 5.9467 mL 14.8668 mL
15 mM 0.3964 mL 1.9822 mL 3.9645 mL 9.9112 mL
20 mM 0.2973 mL 1.4867 mL 2.9734 mL 7.4334 mL
25 mM 0.2379 mL 1.1893 mL 2.3787 mL 5.9467 mL
30 mM 0.1982 mL 0.9911 mL 1.9822 mL 4.9556 mL
40 mM 0.1487 mL 0.7433 mL 1.4867 mL 3.7167 mL
50 mM 0.1189 mL 0.5947 mL 1.1893 mL 2.9734 mL
60 mM 0.0991 mL 0.4956 mL 0.9911 mL 2.4778 mL
80 mM 0.0743 mL 0.3717 mL 0.7433 mL 1.8583 mL
100 mM 0.0595 mL 0.2973 mL 0.5947 mL 1.4867 mL
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MTIC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MTIC3413-72-7Drug MetaboliteTemozolomidebioavailabilitymetabolitepermeabilitybiological barrierstumor cell membraneaffinityInhibitorinhibitorinhibit

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