Enterolactone-d₆

Cat. No.: HY-108692S: FAQs
Data Sheet Handling Instructions

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Enterolactone-d₆ is the deuterium labeled Enterolactone. Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis[2].

For research use only. We do not sell to patients.

Enterolactone-d<sub>6</sub> Chemical Structure

Enterolactone-d₆ Chemical Structure

CAS No. : 104411-11-2

Size	Price	Stock	Quantity
1 mg	USD 1550	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Other Forms of Enterolactone-d₆:

Enterolactone Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

304.37

Formula

C₁₈H₁₂D₆O₄

CAS No.

104411-11-2

Appearance

Solid

Color

White to light yellow

SMILES

C([C@H]1[C@H](CC2=C(C(O)=C(C=C2[2H])[2H])[2H])C(=O)OC1)C3=C(C(O)=C(C=C3[2H])[2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 30 mg/mL (98.56 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2855 mL	16.4274 mL	32.8548 mL
5 mM	0.6571 mL	3.2855 mL	6.5710 mL
10 mM	0.3285 mL	1.6427 mL	3.2855 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Bigdeli B, et al. Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis. Toxicol Appl Pharmacol. 2016;313:180-194. [Content Brief]

[3]. Mali AV, et al. Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial-mesenchymal transition. Cancer Biol Med. 2018;15(2):137-156. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2855 mL	16.4274 mL	32.8547 mL	82.1369 mL
	5 mM	0.6571 mL	3.2855 mL	6.5709 mL	16.4274 mL
	10 mM	0.3285 mL	1.6427 mL	3.2855 mL	8.2137 mL
	15 mM	0.2190 mL	1.0952 mL	2.1903 mL	5.4758 mL
	20 mM	0.1643 mL	0.8214 mL	1.6427 mL	4.1068 mL
	25 mM	0.1314 mL	0.6571 mL	1.3142 mL	3.2855 mL
	30 mM	0.1095 mL	0.5476 mL	1.0952 mL	2.7379 mL
	40 mM	0.0821 mL	0.4107 mL	0.8214 mL	2.0534 mL
	50 mM	0.0657 mL	0.3285 mL	0.6571 mL	1.6427 mL
	60 mM	0.0548 mL	0.2738 mL	0.5476 mL	1.3689 mL
	80 mM	0.0411 mL	0.2053 mL	0.4107 mL	1.0267 mL