Oxythiamine chloride
Based on 3 publication(s) in Google Scholar
Oxythiamine (Hydroxythiamine) chloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride inhibits cancer cell apoptosis and inhibits cell proliferation.
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- CAS No.: 582-36-5
- Formula: C12H16ClN3O2S
- Molecular Weight:301.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Oxythiamine chloride
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Biological Activity
Chemical Information
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CAS No. 582-36-5
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Molecular Weight 301.79
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Formula C12H16ClN3O2S
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SMILES
CC1=C(CCO)SC=[N+]1CC2=CN=C(C)NC2=O.[Cl-]
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Synonyms
Hydroxythiamine chloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Commun
2022 Oct 17;13(1):6121. PMID: 36253417 -
Acta Physiol
Transketolase drives the development of aortic dissection by impairing mitochondrial bioenergetics. [Abstract]2024 Apr;240(4):e14113. PMID: 38380737 -
PLoS Pathog
White spot syndrome virus IE1 protein hijacks the host pentose phosphate pathway to fuel viral replication. [Abstract]2026 Jan 27;22(1):e1013913. PMID: 41592137
Purity & Documentation
References
[1]. Wang J, et al. Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells. Exp Hematol Oncol. 2013 Jul 27;2:18. [Content Brief]
[2]. Raïs B, et al. Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle. FEBS Lett. 1999 Jul 30;456(1):113-8. [Content Brief]
[3]. Bai L, et al. A dose- and time-dependent effect of oxythiamine on cell growth inhibition in non-small cell lung cancer. Cogn Neurodyn. 2022 Jun;16(3):633-641. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Oxythiamine chloride Related Classifications
HY-107430B Related Classifications
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