Normetanephrine hydrochloride
Based on 1 publication(s) in Google Scholar
Normetanephrine ((±)-Normetanephrine) hydrochloride is the O-methylated metabolite of norepinephrine (NE).
For research use only. We do not sell to patients.
- Purity : 99.69%
- CAS No.: 1011-74-1
- Formula: C9H14ClNO3
- Molecular Weight:219.67
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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HY-13715
NorepinephrineAdrenergic Receptor Agonist -
HY-W008794R
Normetanephrine hydrochloride (Standard)Norepinephrine Metabolite -
HY-13715R
Norepinephrine (Standard)Adrenergic Receptor Agonist -
HY-113299
MetanephrineEpinephrine Metabolite -
HY-13715C
Norepinephrine tartrateAdrenergic Receptor Agonist
Publications Citing Use of MedChemExpress (MCE) Normetanephrine hydrochloride
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
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Human Endogenous Metabolite |
In Vitro
Normetanephrine hydrochloride is a norepinephrine metabolite that contains one more methyl group than norepinephrine[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 1011-74-1
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Appearance Solid
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Molecular Weight 219.67
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Formula C9H14ClNO3
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Color White to light yellow
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SMILES
COC1=C(O)C=CC(C(O)CN)=C1.Cl
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Synonyms
(±)-Normetanephrine hydrochloride; DL-Normetanephrine hydrochloride; (Rac)-Normetanephrine hydrochloride
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Neuron
2024 Jun 19;112(12):1930-1942.e6. PMID: 38547869
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (455.23 mM; Need ultrasonic)
DMSO : 20.83 mg/mL (94.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (9.47 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (9.47 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (247 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 4.5523 mL | 22.7614 mL | 45.5228 mL | 113.8071 mL |
| 5 mM | 0.9105 mL | 4.5523 mL | 9.1046 mL | 22.7614 mL | |
| 10 mM | 0.4552 mL | 2.2761 mL | 4.5523 mL | 11.3807 mL | |
| 15 mM | 0.3035 mL | 1.5174 mL | 3.0349 mL | 7.5871 mL | |
| 20 mM | 0.2276 mL | 1.1381 mL | 2.2761 mL | 5.6904 mL | |
| 25 mM | 0.1821 mL | 0.9105 mL | 1.8209 mL | 4.5523 mL | |
| 30 mM | 0.1517 mL | 0.7587 mL | 1.5174 mL | 3.7936 mL | |
| 40 mM | 0.1138 mL | 0.5690 mL | 1.1381 mL | 2.8452 mL | |
| 50 mM | 0.0910 mL | 0.4552 mL | 0.9105 mL | 2.2761 mL | |
| 60 mM | 0.0759 mL | 0.3794 mL | 0.7587 mL | 1.8968 mL | |
| 80 mM | 0.0569 mL | 0.2845 mL | 0.5690 mL | 1.4226 mL | |
| H2O | 100 mM | 0.0455 mL | 0.2276 mL | 0.4552 mL | 1.1381 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Normetanephrine hydrochloride Related Classifications
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