1. Cell Cycle/DNA Damage
    PROTAC
  2. CDK
    Ligands for Target Protein for PROTAC
  3. Abemaciclib metabolite M18 hydrochloride

Abemaciclib metabolite M18 hydrochloride (Synonyms: LSN3106729 hydrochloride)

Cat. No.: HY-126534A Purity: 99.01%
Handling Instructions

Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader.

For research use only. We do not sell to patients.

Abemaciclib metabolite M18 hydrochloride Chemical Structure

Abemaciclib metabolite M18 hydrochloride Chemical Structure

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 409 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 409 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Abemaciclib metabolite M18 hydrochloride:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Abemaciclib metabolite M18 hydrochloride

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  • References

  • Customer Review

Description

Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1].

IC50 & Target[1]

CDK4

 

CDK6

 

Molecular Weight

531.00

Formula

C25H29ClF2N8O

SMILES

FC(C=N1)=C(C2=CC(N(C(C)C)C(CO)=N3)=C3C(F)=C2)N=C1NC4=NC=C(C=C4)CN5CCNCC5.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (235.40 mM; Need ultrasonic)

H2O : 100 mg/mL (188.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8832 mL 9.4162 mL 18.8324 mL
5 mM 0.3766 mL 1.8832 mL 3.7665 mL
10 mM 0.1883 mL 0.9416 mL 1.8832 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Abemaciclib metabolite M18 hydrochloride
Cat. No.:
HY-126534A
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