Abemaciclib metabolite M18 hydrochloride
Based on 3 publication(s) in Google Scholar
Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader.
For research use only. We do not sell to patients.
- Purity: 98.18%
- CAS No.: 2704316-82-3
- Formula: C25H29ClF2N8O
- Molecular Weight:531.00
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Abemaciclib metabolite M18 hydrochloride
More
Biological Activity
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CDK4 |
CDK6 |
Abemaciclib metabolite M18 hydrochloride exhibits T1/2 of 43.1 hr in plasma in healthy subjects[3].
CDK4/6 inhibitors’ chief mechanism of action is inhibition of retinoblastoma (RB) protein phosphorylation and thus the induction of cell cycle arrest, CDK4/6 inhibitors alter cancer cell biology in other ways[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2704316-82-3
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Appearance Solid
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Molecular Weight 531.00
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Formula C25H29ClF2N8O
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Color Off-white to light yellow
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SMILES
FC(C=N1)=C(C2=CC(N(C(C)C)C(CO)=N3)=C3C(F)=C2)N=C1NC4=NC=C(C=C4)CN5CCNCC5.[H]Cl
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Synonyms
LSN3106729 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Pharmaceuticals (Basel)
Development and Application of an UPLC-MS/MS Method for Simultaneous Quantification of Abemaciclib and Tamoxifen with Their Active Metabolites in Rat Plasma: Application to a Pharmacokinetic Study. [Abstract]2026 May 19;19(5):795. PMID: 42198468 -
J Pharm Biomed Anal
Simultaneous quantification of abemaciclib and its active metabolites in human and mouse plasma by UHPLC-MS/MS. [Abstract]2021 Sep 5:203:114225. PMID: 34242947 -
Solvent & Solubility
DMSO : 125 mg/mL (235.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (188.32 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (94.16 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.8832 mL | 9.4162 mL | 18.8324 mL | 47.0810 mL |
| 5 mM | 0.3766 mL | 1.8832 mL | 3.7665 mL | 9.4162 mL | |
| 10 mM | 0.1883 mL | 0.9416 mL | 1.8832 mL | 4.7081 mL | |
| 15 mM | 0.1255 mL | 0.6277 mL | 1.2555 mL | 3.1387 mL | |
| 20 mM | 0.0942 mL | 0.4708 mL | 0.9416 mL | 2.3540 mL | |
| 25 mM | 0.0753 mL | 0.3766 mL | 0.7533 mL | 1.8832 mL | |
| 30 mM | 0.0628 mL | 0.3139 mL | 0.6277 mL | 1.5694 mL | |
| 40 mM | 0.0471 mL | 0.2354 mL | 0.4708 mL | 1.1770 mL | |
| 50 mM | 0.0377 mL | 0.1883 mL | 0.3766 mL | 0.9416 mL | |
| 60 mM | 0.0314 mL | 0.1569 mL | 0.3139 mL | 0.7847 mL | |
| 80 mM | 0.0235 mL | 0.1177 mL | 0.2354 mL | 0.5885 mL | |
| 100 mM | 0.0188 mL | 0.0942 mL | 0.1883 mL | 0.4708 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Abemaciclib metabolite M18 hydrochloride Related Classifications
HY-126534A Related Classifications
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