1-Aminocyclopropane-1-carboxylic acid

Cat. No.: HY-30004 Purity: ≥98.0%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

1-Aminocyclopropane-1-carboxylic acid is an endogenous metabolite. In the presence of low concentrations (1 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a small molecule agonist of NMDA receptors with an EC50 of 0.7-0.9 μM. At high concentrations (10 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a competitive antagonist of NMDA receptors with an EC50 of 81.6 nM. 1-Aminocyclopropane-1-carboxylic acid exerts neuroprotective activity by moderately activating NMDA receptors to prevent neuronal cell death in ischemic animal models. Additionally, 1-Aminocyclopropane-1-carboxylic acid is an antagonist of NMDA receptors, inducing blood pressure reduction and antioxidant effects in stroke-prone hypertensive rats. 1-Aminocyclopropane-1-carboxylic acid enhances object recognition memory and cognitive flexibility dependent on the prefrontal cortex, but does not affect impulsivity nor exhibit an antipsychotic-like profile. 1-Aminocyclopropane-1-carboxylic acid shows promise for research in the field of neurotoxicity..

For research use only. We do not sell to patients.

1-Aminocyclopropane-1-carboxylic acid Chemical Structure

CAS No. : 22059-21-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	Get quote
5 g	Get quote

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Other Forms of 1-Aminocyclopropane-1-carboxylic acid:

1-Aminocyclopropane-1-carboxylic acid-d₄ Get quote
1-Aminocyclopropane-1-carboxylic acid (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

1-Aminocyclopropane-1-carboxylic acid (50mg/kg, i.p.,once a day for 10 days) induces the expression of HO-1, which exerts antioxidant and vascular relaxation effects, thereby suggesting that 1-Aminocyclopropane-1-carboxylic acid normalizes blood pressure elevation and reduces stroke mortality in stroke-prone spontaneously hypertensive rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Stroke-prone spontaneously hypertensive rats (SHRSP)^[3]
Dosage:	50 mg/kg
Administration:	Intraperitoneal (i.p.), once a day for 4 weeks
Result:	Reduced systolic blood pressure in SHRSP. Additionally, it significantly decreased stroke mortality in SHRSP. Administration of 1-Aminocyclopropane-1-carboxylic acid also notably reduced plasma nitrate/nitrite concentration and urinary nitrate/nitrite excretion, and improved relative plasma SOD activity.

Molecular Weight

101.10

Formula

C₄H₇NO₂

CAS No.

22059-21-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1(N)CC1

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (247.28 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.8912 mL	49.4560 mL	98.9120 mL
5 mM	1.9782 mL	9.8912 mL	19.7824 mL
10 mM	0.9891 mL	4.9456 mL	9.8912 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (989.12 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (251 KB) HNMR (115 KB)

Handling Instructions (2659 KB)

References

[1]. Nahum-Levy R,et al. Putative partial agonist 1-aminocyclopropanecarboxylic acid acts concurrently as a glycine-site agonist and a glutamate-site antagonist at N-methyl-D-aspartate receptors. Mol Pharmacol. 1999 Dec;56(6):1207-18. [Content Brief]

[2]. Bleecker AB and Kende H. Ethylene: a gaseous signal molecule in plants. Annu Rev Cell Dev Biol. 2000;16:1-18. [Content Brief]

[3]. Gao, M., Kondo, F., Murakami, T. et al. 1-Aminocyclopropanecarboxylic Acid, an Antagonist of N-Methyl-D-Aspartate Receptors, Causes Hypotensive and Antioxidant Effects with Upregulation of Heme Oxygenase-1 in Stroke-Prone Spontaneously Hypertensive Rats. Hypertens Res, 2007,30, 249–257. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	9.8912 mL	49.4560 mL	98.9120 mL	247.2799 mL
	5 mM	1.9782 mL	9.8912 mL	19.7824 mL	49.4560 mL
	10 mM	0.9891 mL	4.9456 mL	9.8912 mL	24.7280 mL
	15 mM	0.6594 mL	3.2971 mL	6.5941 mL	16.4853 mL
	20 mM	0.4946 mL	2.4728 mL	4.9456 mL	12.3640 mL
	25 mM	0.3956 mL	1.9782 mL	3.9565 mL	9.8912 mL
	30 mM	0.3297 mL	1.6485 mL	3.2971 mL	8.2427 mL
	40 mM	0.2473 mL	1.2364 mL	2.4728 mL	6.1820 mL
	50 mM	0.1978 mL	0.9891 mL	1.9782 mL	4.9456 mL
	60 mM	0.1649 mL	0.8243 mL	1.6485 mL	4.1213 mL
	80 mM	0.1236 mL	0.6182 mL	1.2364 mL	3.0910 mL
	100 mM	0.0989 mL	0.4946 mL	0.9891 mL	2.4728 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.