Xanthine oxidase, Microorganism
Based on 6 publication(s) in Google Scholar
Xanthine oxidase, Microorganism (XO) is a xanthine oxidoreductase enzyme that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid.
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- No. CAS: 9002-17-9
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Almacenamiento:
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) Xanthine oxidase, Microorganism
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Actividad biológica
Xanthine oxidase rapidly and completely depletes hypoxanthine in human erythrocytes[2].
Xanthine oxidase (20 mU/mL, 72 h) inhibits growth of Plasmodium falciparum in human erythrocytes[2].
Xanthine oxidase (0.02 U/mL, 6 h) reduces the viability of postnatal cerebellar granule neurons obtained from 8-day old Sprague-Dawley rat pups[3].
Product Information
Optimal pH: 7.5-8.0
Theoretical molecular weight: 283 kDa (mostly exists in dimer form)
Instructions
Soluble in water (10 mg/mL), Or dissolve in buffer according to specific experimental references (such as 50 mM potassium phosphate).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
1.17.3.2
≥10 U/mg soild
≥50 U/mg protein
One unit is defined as the amount of enzyme that convert 1 μmol of xanthine to uric acid per minute at 37°C and pH 7.5
Chemical Information
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No. CAS 9002-17-9
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Appearance Solid
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Color Off-white to yellow
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SMILES
[Xanthine oxidase, Microorganism]
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Synonyms
XO; XOD
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Adv Mater
Nanozyme-Reinforced Hydrogel Spray as a Reactive Oxygen Species-Driven Oxygenator to Accelerate Diabetic Wound Healing. [Abstract]2025 Aug;37(34):e2504829. PMID: 40492891 -
Asian J Pharm Sci
A programmable nanoreactor for photothermal immunotherapy via NIR-II triggered enzyme-catalyzed immunogenic tumor microenvironment remodeling. [Abstract]2026 Apr;21(2):101150. PMID: 42023164 -
Chin Med
A novel Chinese medicine formula against hyperuricemia-induced kidney inflammation involving pyroptosis inhibition via modulating AMPK-TLR4-NLRP3 pathway. [Abstract]2026 Mar 1;21(1):74. PMID: 41764514 -
Colloids Surf B Biointerfaces
In-situ growth of CeO2 on biofilms: Innovative nanoparticles for photothermal therapy & multi-pronged attack on Alzheimer's disease. [Abstract]2024 Jun:238:113887. PMID: 38581835 -
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Solvente y solubilidad
H2O : ≥ 10 mg/mL
* "≥" means soluble, but saturation unknown.
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[2]. Berman PA, et al. Xanthine oxidase inhibits growth of Plasmodium falciparum in human erythrocytes in vitro. J Clin Invest. 1991 Dec;88(6):1848-55. [Content Brief]
[3]. Fatokun AA, et al. Hydrogen peroxide mediates damage by xanthine and xanthine oxidase in cerebellar granule neuronal cultures. Neurosci Lett. 2007 Apr 6;416(1):34-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Xanthine oxidase, Microorganism Related Classifications
HY-P2755 Related Classifications
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