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  3. GW7604

GW7604 

Cat. No.: HY-117153
Handling Instructions

GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist.

For research use only. We do not sell to patients.

GW7604 Chemical Structure

GW7604 Chemical Structure

CAS No. : 195611-82-6

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Description

GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist[1].

In Vitro

GW7604 is the presumed metabolite of GW5638 in breast (MCF-7) and endometrial (ECC-1) cell lines. GW7604 (0.1 nM-1 μM; 24 hours) inhibits both Estradiol (1 nM) and 4-hydroxytamoxifen (4-OHT; 10 and 100 nM) induction of TGF-alpha in a concentration related manner (1-1000 nM) in MDA-MB-231 cells[1].

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM
Incubation Time: 24 hours
Result: Blocked the effect of estradiol (E2; 1 n M) in a concentration-related manner.
Molecular Weight

370.44

Formula

C₂₅H₂₂O₃

CAS No.

195611-82-6

SMILES

O=C(O)/C=C/C1=CC=C(/C(C2=CC=C(O)C=C2)=C(C3=CC=CC=C3)/CC)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
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