2. Cell Cycle/DNA Damage Neuronal Signaling
  3. Topoisomerase Cholinesterase (ChE)
  4. RPR121056

RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE.

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RPR121056 Chemical Structure

RPR121056 Chemical Structure

CAS No. : 181467-56-1

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5 mg USD 350 In-stock
10 mg USD 550 In-stock
25 mg USD 1100 In-stock
50 mg USD 1760 In-stock
100 mg USD 2820 In-stock
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Based on 1 publication(s) in Google Scholar

RPR121056 Related Antibodies

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

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AChE BChE

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Description

RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE[1].

IC50 & Target

AChE

 

Molecular Weight

618.68

Formula

C33H38N4O8
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1CCC(NCCCCC(O)=O)CC1)OC2=CC=C3N=C4C(CN5C(C(COC([C@@]6(CC)O)=O)=C6C=C54)=O)=C(CC)C3=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (323.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6163 mL 8.0817 mL 16.1634 mL
5 mM 0.3233 mL 1.6163 mL 3.2327 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6163 mL 8.0817 mL 16.1634 mL 40.4086 mL
5 mM 0.3233 mL 1.6163 mL 3.2327 mL 8.0817 mL
10 mM 0.1616 mL 0.8082 mL 1.6163 mL 4.0409 mL
15 mM 0.1078 mL 0.5388 mL 1.0776 mL 2.6939 mL
20 mM 0.0808 mL 0.4041 mL 0.8082 mL 2.0204 mL
25 mM 0.0647 mL 0.3233 mL 0.6465 mL 1.6163 mL
30 mM 0.0539 mL 0.2694 mL 0.5388 mL 1.3470 mL
40 mM 0.0404 mL 0.2020 mL 0.4041 mL 1.0102 mL
50 mM 0.0323 mL 0.1616 mL 0.3233 mL 0.8082 mL
60 mM 0.0269 mL 0.1347 mL 0.2694 mL 0.6735 mL
80 mM 0.0202 mL 0.1010 mL 0.2020 mL 0.5051 mL
100 mM 0.0162 mL 0.0808 mL 0.1616 mL 0.4041 mL
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RPR121056 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RPR121056181467-56-1APCRPR 121056RPR-121056TopoisomeraseCholinesterase (ChE)IrinotecanmetaboliteantineoplasticCYP3A4topoisomerase-IInhibitorinhibitorinhibit

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