2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Ranitidine S-oxide

Ranitidine S-oxide is the metabolite of Ranitidine (HY-B0693). Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion.

For research use only. We do not sell to patients.

Ranitidine S-oxide Chemical Structure

Ranitidine S-oxide Chemical Structure

CAS No. : 73851-70-4

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Description

Ranitidine S-oxide is the metabolite of Ranitidine (HY-B0693). Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion[1][2].

Molecular Weight

330.40

Formula

C13H22N4O4S
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

O=[N+](/C=C(NCCS(CC1=CC=C(CN(C)C)O1)=O)\NC)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (378.33 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0266 mL 15.1332 mL 30.2663 mL
5 mM 0.6053 mL 3.0266 mL 6.0533 mL
View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.0266 mL 15.1332 mL 30.2663 mL 75.6659 mL
5 mM 0.6053 mL 3.0266 mL 6.0533 mL 15.1332 mL
10 mM 0.3027 mL 1.5133 mL 3.0266 mL 7.5666 mL
15 mM 0.2018 mL 1.0089 mL 2.0178 mL 5.0444 mL
20 mM 0.1513 mL 0.7567 mL 1.5133 mL 3.7833 mL
25 mM 0.1211 mL 0.6053 mL 1.2107 mL 3.0266 mL
30 mM 0.1009 mL 0.5044 mL 1.0089 mL 2.5222 mL
40 mM 0.0757 mL 0.3783 mL 0.7567 mL 1.8916 mL
50 mM 0.0605 mL 0.3027 mL 0.6053 mL 1.5133 mL
60 mM 0.0504 mL 0.2522 mL 0.5044 mL 1.2611 mL
80 mM 0.0378 mL 0.1892 mL 0.3783 mL 0.9458 mL
100 mM 0.0303 mL 0.1513 mL 0.3027 mL 0.7567 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ranitidine S-oxide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ranitidine S-oxide73851-70-4Drug MetabolitemetaboliteRanitidinegastric secretionInhibitorinhibitorinhibit

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