1. Cytoskeleton
  2. Integrin
  3. RO0270608

RO0270608 

Cat. No.: HY-138542
Handling Instructions

RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. Antiinflammatory activity.

For research use only. We do not sell to patients.

RO0270608 Chemical Structure

RO0270608 Chemical Structure

CAS No. : 220846-33-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 389 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 580 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. Antiinflammatory activity[1][2].

IC50 & Target[1]

α4β1

 

α4β7

 

In Vitro

RO0270608 inhibits α4/β7 mediated cell adhesion with an IC50 of 33 nM. In a human T-cell VCAM/anti CD3 costimulation assay RO0270608 causes a pronounced inhibition of T-cell proliferation (IC50=30 nM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In a murine OVA-model of airway inflammation, RO0270608 i.n. abolishes allergen-induced inflammatory cell accumulation[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

505.78

Formula

C₂₄H₁₉Cl₃N₂O₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
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Product Name:
RO0270608
Cat. No.:
HY-138542
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