2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate

2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate 

Cat. No.: HY-W016812 Purity: 99.90%
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2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate is an endogenous metabolite.

For research use only. We do not sell to patients.

2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate Chemical Structure

2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate Chemical Structure

CAS No. : 50887-69-9

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Based on 1 publication(s) in Google Scholar

Other Forms of 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate:

2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate Related Antibodies

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Description

2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate is an endogenous metabolite.

Molecular Weight

174.11

Formula

C5H6N2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1)NC(C(O)=O)=CC1=O.O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (574.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7435 mL 28.7175 mL 57.4350 mL
5 mM 1.1487 mL 5.7435 mL 11.4870 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (14.36 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.7435 mL 28.7175 mL 57.4350 mL 143.5874 mL
5 mM 1.1487 mL 5.7435 mL 11.4870 mL 28.7175 mL
10 mM 0.5743 mL 2.8717 mL 5.7435 mL 14.3587 mL
15 mM 0.3829 mL 1.9145 mL 3.8290 mL 9.5725 mL
20 mM 0.2872 mL 1.4359 mL 2.8717 mL 7.1794 mL
25 mM 0.2297 mL 1.1487 mL 2.2974 mL 5.7435 mL
30 mM 0.1914 mL 0.9572 mL 1.9145 mL 4.7862 mL
40 mM 0.1436 mL 0.7179 mL 1.4359 mL 3.5897 mL
50 mM 0.1149 mL 0.5743 mL 1.1487 mL 2.8717 mL
60 mM 0.0957 mL 0.4786 mL 0.9572 mL 2.3931 mL
80 mM 0.0718 mL 0.3590 mL 0.7179 mL 1.7948 mL
100 mM 0.0574 mL 0.2872 mL 0.5743 mL 1.4359 mL
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2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid50887-69-9Endogenous MetaboliteInhibitorinhibitorinhibit

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