1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. Nucleoside Antimetabolite/Analog
    Endogenous Metabolite
  3. Orotic acid

Orotic acid (Synonyms: 6-Carboxyuracil; Vitamin B13)

Cat. No.: HY-N0157 Purity: 98.14%
Handling Instructions

Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats.

For research use only. We do not sell to patients.

Orotic acid Chemical Structure

Orotic acid Chemical Structure

CAS No. : 65-86-1

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Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
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ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
100 mg USD 66 In-stock
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500 mg USD 119 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Orotic acid:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Orotic acid

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Orotic acid is found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Orotic acid is a marker for measurement of urea cycle disorders (UCDs), including ornithine transcarbamylase deficiency (OTCD)[2].
Orotic acid (1.0% addition to the diet; p.o. for 3-10 d) induces a development of fatty liver by day 7, and decreases purine/pyrimidine ratio of hepatic acid-soluble nucleotides by day 3[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

156.10

Formula

C5H4N2O4

CAS No.
SMILES

O=C(C(NC1=O)=CC(N1)=O)O

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 55 mg/mL (352.34 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4061 mL 32.0308 mL 64.0615 mL
5 mM 1.2812 mL 6.4061 mL 12.8123 mL
10 mM 0.6406 mL 3.2031 mL 6.4061 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (17.62 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 98.14%

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Orotic acid
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HY-N0157
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