Orotic acid zinc
Based on 4 publication(s) in Google Scholar
Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats.
For research use only. We do not sell to patients.
- Purity: 99.84%
- CAS No.: 68399-76-8
- Formula: C5H4N2O4Zn0.5
- Molecular Weight:188.79
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Orotic acid zinc
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Orotic acid is found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Orotic acid (1.0% addition to the diet; p.o. for 3-10 d) induces a development of fatty liver by day 7, and decreases purine/pyrimidine ratio of hepatic acid-soluble nucleotides by day 3[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 68399-76-8
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Appearance Solid
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Molecular Weight 188.79
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Formula C5H4N2O4Zn0.5
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Color White to off-white
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SMILES
O=C(C(NC1=O)=CC(N1)=O)O.[0.5Zn]
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Synonyms
6-Carboxyuracil zinc; Vitamin B13 zinc
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Autophagy
2026 Jul;22(7):1657-1678. PMID: 41968644 -
J Adv Res
Antimycin A inhibits alpha-herpesvirus replication by disrupting the formation of pyrimidinosomes. [Abstract]2025 May 10:S2090-1232(25)00309-1. PMID: 40354935 -
J Mol Med (Berl)
2019 Aug;97(8):1183-1193. PMID: 31201471
Solvent & Solubility
DMSO : 20 mg/mL (105.94 mM; ultrasonic and adjust pH to 2 with 1 M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Löffler M, et, al. Orotate (orotic acid): An essential and versatile molecule. Nucleosides Nucleotides Nucleic Acids. [Content Brief]
[2]. Staretz-Chacham O, et, al. The role of orotic acid measurement in routine newborn screening for urea cycle disorders. J Inherit Metab Dis. 2020 Nov 15. [Content Brief]
[3]. Durschlag RP, et, al. Orotic acid-induced metabolic changes in the rat. J Nutr. 1980 Apr;110(4):816-21. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.2969 mL | 26.4845 mL | 52.9689 mL | 132.4223 mL |
| 5 mM | 1.0594 mL | 5.2969 mL | 10.5938 mL | 26.4845 mL | |
| 10 mM | 0.5297 mL | 2.6484 mL | 5.2969 mL | 13.2422 mL | |
| 15 mM | 0.3531 mL | 1.7656 mL | 3.5313 mL | 8.8282 mL | |
| 20 mM | 0.2648 mL | 1.3242 mL | 2.6484 mL | 6.6211 mL | |
| 25 mM | 0.2119 mL | 1.0594 mL | 2.1188 mL | 5.2969 mL | |
| 30 mM | 0.1766 mL | 0.8828 mL | 1.7656 mL | 4.4141 mL | |
| 40 mM | 0.1324 mL | 0.6621 mL | 1.3242 mL | 3.3106 mL | |
| 50 mM | 0.1059 mL | 0.5297 mL | 1.0594 mL | 2.6484 mL | |
| 60 mM | 0.0883 mL | 0.4414 mL | 0.8828 mL | 2.2070 mL | |
| 80 mM | 0.0662 mL | 0.3311 mL | 0.6621 mL | 1.6553 mL | |
| 100 mM | 0.0530 mL | 0.2648 mL | 0.5297 mL | 1.3242 mL |
Orotic acid zinc Related Classifications
HY-N0157A Related Classifications
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