1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. Nucleoside Antimetabolite/Analog
    Endogenous Metabolite
  3. Orotic acid zinc

Orotic acid zinc 

Cat. No.: HY-N0157A
Handling Instructions

Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats.

For research use only. We do not sell to patients.

Orotic acid zinc Chemical Structure

Orotic acid zinc Chemical Structure

CAS No. : 68399-76-8

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Description

Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats[1][2][3].

In Vitro

Orotic acid is found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Orotic acid is a marker for measurement of urea cycle disorders (UCDs), including ornithine transcarbamylase deficiency (OTCD)[2].
Orotic acid (1.0% addition to the diet; p.o. for 3-10 d) induces a development of fatty liver by day 7, and decreases purine/pyrimidine ratio of hepatic acid-soluble nucleotides by day 3[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

188.79

Formula

C5H4N2O4Zn0.5

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Orotic acid zinc
Cat. No.:
HY-N0157A
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