65-86-1
65-86-1
Chemical Structure
Orotic acid
Synonym(s): 6-Carboxyuracil; Vitamin B13
- CAS No.: 65-86-1
- Formula:C5H4N2O4
- Molecular Weight:156.10
IUPAC Name: 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
InChIKey: PXQPEWDEAKTCGB-UHFFFAOYSA-N
SMILES: O=C(C(NC1=O)=CC(N1)=O)O
Biological Activity: Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Orotic acid | 99.98% | Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats. | ||||||||||||||||||||
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Orotic acid (Standard) | 99.51% | Orotic acid (Standard) is the analytical standard of Orotic acid. This product is intended for research and analytical applications. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats. | ||||||||||||||||||||
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6-Azathymine acid | 6-Azathymine acid is a metabolite of Pymetrozine. Pymetrozine is active against plant-sucking insects, such as aphids and whiteflies in vegetables, cotton, field crops and fruits and affects the nervous regulation of feeding behavior. | |||||||||||||||||||||
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2,4-Dihydroxypyrimidine-5-carboxylic Acid | 99.90% | 2,4-Dihydroxypyrimidine-5-carboxylic acid (Uracil-5-carboxylic acid) is a linker. 2,4-Dihydroxypyrimidine-5-carboxylic acid can be assembled with various metal ions. 2,4-Dihydroxypyrimidine-5-carboxylic acid can be enzymatically converted to Uracil (HY-I0960). | ||||||||||||||||||||
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Orotic acid potassium | 99.51% | Orotic acid potassium (Vitamin B13 potassium) is a precursor of pyrimidine bases and is involved in the synthesis of DNA and RNA. Orotic acid potassium stimulates the growth of animals, plants and microorganisms, participates in carbohydrate metabolism, and is necessary for the growth and life activities of organisms. Orotic acid potassium is a measurement indicator in routine newborn screening for urea cycle abnormalities. Orotic acid potassium can cause hepatic steatosis and hepatomegaly in rats. | ||||||||||||||||||||
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Orotic acid-13C,15N2 monohydrate | 99.80% | Orotic acid-13C,15N2 (monohydrate) is the 13C and 15N labeled Orotic acid. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats. | ||||||||||||||||||||
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Orotic acid hydrate | 99.94% | Orotic acid hydrate is an endogenous metabolite. | ||||||||||||||||||||
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5-Fluoroorotic acid | 99.17% | 5-Fluoroorotic acid is the inhibitor for thymidylate synthase that acts as a selective agent in yeast molecular genetics. 5-Fluoroorotic acid exhibits antimalarial activity. | ||||||||||||||||||||
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5-Fluoroorotic acid monohydrate | 99.39% | 5-Fluoroorotic acid monohydrate is the monohydrate salt form of 5-Fluoroorotic acid (HY-W016819). 5-Fluoroorotic acid monohydrate is the inhibitor for thymidylate synthase that acts as a selective agent in yeast molecular genetics. 5-Fluoroorotic acid monohydrate exhibits antimalarial activity. | ||||||||||||||||||||
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Citrazinic acid | 99.69% | Citrazinic acid is a weakly fluorescent compound whose optical properties are dependent on aggregation states and chemical environment. Citrazinic acid strongly tends to form dimers at high concentrations. | ||||||||||||||||||||
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Lithium orotate | 99.82% | Lithium orotate is an orally active lithium supplement with reduced binding that can bypass amyloid sequestration in AD mice models. Lithium orotate can prevent Aβ plaque deposition and phospho-tau accumulation and reverse AD pathology, neuroinflammatory changes and memory loss in AD mice models and ageing wild-type mice. Lithium orotate can be used for the research of alcoholism and Alzheimer’s disease. | ||||||||||||||||||||
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6-Methyluracil | 99.69% | 6-Methyluracil (Pseudothymine), a metabolite of Uracil, can be used as an indicator of acetoacetyl-CoA (AACoA) accumulation. 6-Methyluracil exhibits antiradiation effect in vivo. | ||||||||||||||||||||
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References
- [1]. Löffler M, et, al. Orotate (orotic acid): An essential and versatile molecule. Nucleosides Nucleotides Nucleic Acids. [Content Brief]
- [2]. Staretz-Chacham O, et, al. The role of orotic acid measurement in routine newborn screening for urea cycle disorders. J Inherit Metab Dis. 2020 Nov 15. [Content Brief]
- [3]. Durschlag RP, et, al. Orotic acid-induced metabolic changes in the rat. J Nutr. 1980 Apr;110(4):816-21. [Content Brief]
