Lithium orotate
Based on 1 Customer Validation
Lithium orotate is an orally active lithium supplement with reduced binding that can bypass amyloid sequestration in AD mice models. Lithium orotate can prevent Aβ plaque deposition and phospho-tau accumulation and reverse AD pathology, neuroinflammatory changes and memory loss in AD mice models and ageing wild-type mice. Lithium orotate can be used for the research of alcoholism and Alzheimer’s disease.
For research use only. We do not sell to patients.
- Purity: 99.82%
- CAS No.: 5266-20-6
- Formula: C5H3LiN2O4
- Molecular Weight:162.03
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Lithium orotate (0-500 μM; 16 h) has low binding ability to synthetic human Aβ1-42 fibrils and oligomers[2].
Lithium orotate (20-500 μM; 6 h pre-treatment) promotes microglial uptake and degradation of Aβ42 in BV2 microglial cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3xTg mice carried APPSwe and tauP301L
mutant transgenes and ageing wild-type mice[2] -
Dosage:4.3 and 130 µM
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Administration:p.o.; in drinking water
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Result:Almost completely prevented Aβ plaque deposition and phospho-tau accumulation in 3xTg mice.
Reversed memory loss in 3xTg mice and improved.
Prevented age-related microgliosis, astrogliosis, synapse loss, and cognitive decline in wild-type mice.
Chemical Information
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CAS No. 5266-20-6
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Appearance Solid
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Molecular Weight 162.03
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Formula C5H3LiN2O4
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SMILES
O=C1C=C(C(O[Li])=O)NC(N1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 6.67 mg/mL (41.17 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.1717 mL | 30.8585 mL | 61.7170 mL | 154.2924 mL |
| 5 mM | 1.2343 mL | 6.1717 mL | 12.3434 mL | 30.8585 mL | |
| 10 mM | 0.6172 mL | 3.0858 mL | 6.1717 mL | 15.4292 mL | |
| 15 mM | 0.4114 mL | 2.0572 mL | 4.1145 mL | 10.2862 mL | |
| 20 mM | 0.3086 mL | 1.5429 mL | 3.0858 mL | 7.7146 mL | |
| 25 mM | 0.2469 mL | 1.2343 mL | 2.4687 mL | 6.1717 mL | |
| 30 mM | 0.2057 mL | 1.0286 mL | 2.0572 mL | 5.1431 mL | |
| 40 mM | 0.1543 mL | 0.7715 mL | 1.5429 mL | 3.8573 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Lithium orotate Related Classifications
HY-W841438 Related Classifications
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