Orotic acid-13C,15N2 monohydrate
Based on 1 Customer Validation
Orotic acid-13C,15N2 (monohydrate) is the 13C and 15N labeled Orotic acid. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 1346602-15-0
- Formula: C413CH615N2O5
- Molecular Weight:177.09
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1346602-15-0
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Unlabeled Cas 50887-69-9
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Appearance Solid
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Molecular Weight 177.09
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Formula C413CH615N2O5
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Color White to light yellow
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SMILES
OC(C1=CC([15NH][13C]([15NH]1)=O)=O)=O.O
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Synonyms
6-Carboxyuracil-13C,15N2 monohydrate; Vitamin B13-13C,15N2 monohydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 55 mg/mL (310.58 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Löffler M, et, al. Orotate (orotic acid): An essential and versatile molecule. Nucleosides Nucleotides Nucleic Acids. [Content Brief]
[3]. Staretz-Chacham O, et, al. The role of orotic acid measurement in routine newborn screening for urea cycle disorders. J Inherit Metab Dis. 2020 Nov 15. [Content Brief]
[4]. Durschlag RP, et, al. Orotic acid-induced metabolic changes in the rat. J Nutr. 1980 Apr110(4):816-21. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.6468 mL | 28.2342 mL | 56.4685 mL | 141.1712 mL |
| 5 mM | 1.1294 mL | 5.6468 mL | 11.2937 mL | 28.2342 mL | |
| 10 mM | 0.5647 mL | 2.8234 mL | 5.6468 mL | 14.1171 mL | |
| 15 mM | 0.3765 mL | 1.8823 mL | 3.7646 mL | 9.4114 mL | |
| 20 mM | 0.2823 mL | 1.4117 mL | 2.8234 mL | 7.0586 mL | |
| 25 mM | 0.2259 mL | 1.1294 mL | 2.2587 mL | 5.6468 mL | |
| 30 mM | 0.1882 mL | 0.9411 mL | 1.8823 mL | 4.7057 mL | |
| 40 mM | 0.1412 mL | 0.7059 mL | 1.4117 mL | 3.5293 mL | |
| 50 mM | 0.1129 mL | 0.5647 mL | 1.1294 mL | 2.8234 mL | |
| 60 mM | 0.0941 mL | 0.4706 mL | 0.9411 mL | 2.3529 mL | |
| 80 mM | 0.0706 mL | 0.3529 mL | 0.7059 mL | 1.7646 mL | |
| 100 mM | 0.0565 mL | 0.2823 mL | 0.5647 mL | 1.4117 mL |
Orotic acid-13C,15N2 monohydrate Related Classifications
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