5-Carboxy-2′-deoxyuridine

Cat. No.: HY-W424779 Pureza: 99.28%: Ficha de datos
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5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine. 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine.

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5-Carboxy-2′-deoxyuridine Estructura química

No. CAS : 14599-46-3

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Based on 1 Customer Validation

Other Forms of 5-Carboxy-2′-deoxyuridine:

5-Carboxy-2′-deoxyuridine (Standard) Obtener un presupuesto

Recomendaciones destacadas

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•Related Proteins:

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Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine^[1]. 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine^[2].

Fòrmula

C₁₀H₁₂N₂O₇

No. CAS

14599-46-3

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1C[C@H](N2C(NC(C(C(O)=O)=C2)=O)=O)O[C@@H]1CO

Peso molecular

272.21

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 125 mg/mL (459.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 5 mg/mL (18.37 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6736 mL	18.3682 mL	36.7363 mL
5 mM	0.7347 mL	3.6736 mL	7.3473 mL
10 mM	0.3674 mL	1.8368 mL	3.6736 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.28%

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Ficha de datos (276 KB) SDS (396 KB)

COA (256 KB) HNMR (179 KB) RP-HPLC (244 KB) MS (71 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. V Guerniou, et al. New synthesis of 5-carboxy-2'-deoxyuridine and its incorporation into synthetic oligonucleotides. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1073-5. [Content Brief]

[2]. D Pavan-Langston, et al. Intraocular penetration of trifluridine. Am J Ophthalmol. 1979 Jun;87(6):814-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.6736 mL	18.3682 mL	36.7363 mL	91.8409 mL
	5 mM	0.7347 mL	3.6736 mL	7.3473 mL	18.3682 mL
	10 mM	0.3674 mL	1.8368 mL	3.6736 mL	9.1841 mL
	15 mM	0.2449 mL	1.2245 mL	2.4491 mL	6.1227 mL
DMSO	20 mM	0.1837 mL	0.9184 mL	1.8368 mL	4.5920 mL
	25 mM	0.1469 mL	0.7347 mL	1.4695 mL	3.6736 mL
	30 mM	0.1225 mL	0.6123 mL	1.2245 mL	3.0614 mL
	40 mM	0.0918 mL	0.4592 mL	0.9184 mL	2.2960 mL
	50 mM	0.0735 mL	0.3674 mL	0.7347 mL	1.8368 mL
	60 mM	0.0612 mL	0.3061 mL	0.6123 mL	1.5307 mL
	80 mM	0.0459 mL	0.2296 mL	0.4592 mL	1.1480 mL
	100 mM	0.0367 mL	0.1837 mL	0.3674 mL	0.9184 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.