5-Carboxy-2′-deoxyuridine
Based on 1 Customer Validation
5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine. 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine.
For research use only. We do not sell to patients.
- Purity: 99.28%
- CAS No.: 14599-46-3
- Formula: C10H12N2O7
- Molecular Weight:272.21
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 14599-46-3
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Appearance Solid
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Molecular Weight 272.21
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Formula C10H12N2O7
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Color White to off-white
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SMILES
O[C@H]1C[C@H](N2C(NC(C(C(O)=O)=C2)=O)=O)O[C@@H]1CO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : 125 mg/mL (459.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 5 mg/mL (18.37 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. V Guerniou, et al. New synthesis of 5-carboxy-2'-deoxyuridine and its incorporation into synthetic oligonucleotides. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1073-5. [Content Brief]
[2]. D Pavan-Langston, et al. Intraocular penetration of trifluridine. Am J Ophthalmol. 1979 Jun;87(6):814-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.6736 mL | 18.3682 mL | 36.7363 mL | 91.8409 mL |
| 5 mM | 0.7347 mL | 3.6736 mL | 7.3473 mL | 18.3682 mL | |
| 10 mM | 0.3674 mL | 1.8368 mL | 3.6736 mL | 9.1841 mL | |
| 15 mM | 0.2449 mL | 1.2245 mL | 2.4491 mL | 6.1227 mL | |
| DMSO | 20 mM | 0.1837 mL | 0.9184 mL | 1.8368 mL | 4.5920 mL |
| 25 mM | 0.1469 mL | 0.7347 mL | 1.4695 mL | 3.6736 mL | |
| 30 mM | 0.1225 mL | 0.6123 mL | 1.2245 mL | 3.0614 mL | |
| 40 mM | 0.0918 mL | 0.4592 mL | 0.9184 mL | 2.2960 mL | |
| 50 mM | 0.0735 mL | 0.3674 mL | 0.7347 mL | 1.8368 mL | |
| 60 mM | 0.0612 mL | 0.3061 mL | 0.6123 mL | 1.5307 mL | |
| 80 mM | 0.0459 mL | 0.2296 mL | 0.4592 mL | 1.1480 mL | |
| 100 mM | 0.0367 mL | 0.1837 mL | 0.3674 mL | 0.9184 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
5-Carboxy-2′-deoxyuridine Related Classifications
HY-W424779 Related Classifications
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